CRP与在体兔动脉粥样硬化相关性的研究及桑葚提取物的影响  

The Correlation of Serum C-reactive Protein and Atherosclerosis and Intervention Effect of Mulberry Sarcocarp Extract

作　　者：王晓杨[1] 张志琴[1] 张媛[1] 余勇[1] 毛宇飞[1] 

机构地区：[1]浙江金华职业技术学院医学院

出　　处：《中西医结合心脑血管病杂志》2009年第9期1053-1055,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：浙江省金华市科技局基金资助课题(No.2007-3-055)

摘　　要：目的探讨炎症敏感指标C-反应蛋白(CRP)与实验性高脂饮食新西兰兔动脉粥样硬化的相关性及桑葚提取物对其的影响。方法36只新西兰兔随机分为6组,正常对照组给予普通饮食;模型组给予高脂饮食;血脂康阳性对照组予高脂饮食加血脂康;预防用药组将桑葚提取液与高脂饲料喂养新西兰兔,该组又分为低剂量组(1g/kg)、中剂量组(5g/kg),高剂量组(10g/kg)。于用药即刻、2周、4周、6周、8周末时测定血清CRP的含量,8周末杀兔取胸主动脉,测定动脉内膜的厚度确定动脉粥样硬化的程度。分析CRP与动脉内膜厚度的相关性。结果从实验第2周起与正常对照组相比模型组兔血清CRP含量显著升高(P<0.01),桑葚3个剂量组与模型组相比CRP含量显著降低(P<0.01);与正常对照组比较模型组动脉内膜显著增厚(P<0.01);与模型组相比桑葚3个剂量组动脉内膜的厚度显著减小(P<0.01);CRP浓度与动脉内膜厚度呈显著正相关(r=0.56,P<0.01)。结论CRP与动脉粥样粥样硬化的形成呈正相关。桑葚提取物可有效降低高脂饮食新西兰兔血清CRP的水平,从而抑制和延缓兔动脉粥样硬化的形成。Objective To investigate the correlation of serum C - reactive protein and atherosclerosis in New Zealand rabbit with high fat diet and the intervention effect of mulberry sarcocarp extract（EMS）. Methods Thirty - six rabbits were divided into 6 group： Normal control group fed ordinary diet,model group fed high fat diet,Xuezhikang capsule group fed high fat diet plus Xuezhikang cap- sule and EMS group fed high fat diet plus EMS. EMS group were divided into three sub - group：Low dose EMS group（1 g/kg） ,middle dose EMS group（5 g/kg） and high dose EMS group（10 g/kg）. The levels of CRP at the end of 0 week,2nd week,4th week and 8th week were measured respectively. At the end of 8 week,rabbits were killed and the aorta were taken to measure the thickness and to definite degree of atherosclerosis. Results Compared with the normal control group, the levels of serum CRP in the model group were increased obviously （P〈0.01）. Comparing with model group, the levels of serum CRP in three EMS sub -group were decreased significantly （P〈0.01）. There was a positive correlation between serum CRP concentration and the atherosclcrosis （r=0.56, P〈0.01）. Conclusion There was a positive correlation between serum CRP concentration and the atherosclerosis. The EMS could decrease effectively the level of serum CRP to inhibit the atherosclerosis formation in rabbits.

关 键 词：C-反应蛋白 桑葚提取液 高脂血症 新西兰兔 动脉粥样硬化 

分 类 号：R285.5[医药卫生—中药学]