蛤毒素的研究进展  

A review on the study of pectenotoxins

作　　者：李兆新[1] 郭萌萌[1] 杨守国[1,2] 邢丽红[1] 谭志军[1] 

机构地区：[1]中国水产科学研究院黄海水产研究所,青岛266071 [2]上海海洋大学水产与生命学院,201306

出　　处：《渔业科学进展》2009年第4期131-141,共11页Progress in Fishery Sciences

基　　金：国家科技支撑计划项目(2007BAD621305)资助

摘　　要：蛤毒素是由有毒甲藻产生的脂溶性毒素,已经确认的同系物有14种。在不同国家的不同贝类中蛤毒素组成特征和含量均存在差异。蛤毒素的小鼠腹腔注射毒性大于经口毒性。目前,国际上蛤毒素的食用安全限量标准尚不统一。蛤毒素的总量可用生物法测定,每种蛤毒素组分的含量可用液相色谱-质谱法测试。蛤毒素的酶联免疫测定方法正在研究阶段。我国关于蛤毒素的研究较少,建议加强对毒素的生物学特征及代谢规律研究。Pectenotoxins area group of lipophilic toxins produced by dinoflagellates. There are 14 pectenotoxin analogues which have been confirmed. The profiles and the concen- tration of pectenotoxins are different in toxic algal and shellfish from different countries. The lethality of pectenotoxins by intra-peritoneal injection is higher than by oral administration of mouse. At present, there are no internationally accepted criteria of maximum residue limits of pectenotoxins for shellfish. The total amount of pectenotoxins can be tested by mouse bioassay. The concentration levels of individual pectenotoxin can be analyzed by HPLC-MS methods. The enzyme-linked immuno sorbent assay（ELISA） method for determination of pectenotoxin is un- der development. In China, few studies on pectenotoxins have been carried out. The studies on profiles and metabolism of pectenotoxins in shellfish are recommended.

关 键 词：蛤毒素 甲藻 双壳贝类 分布 安全限量 

分 类 号：X55[环境科学与工程—环境工程]