雷公藤多甙治疗人工晶体植入术后眼内炎症反应的临床研究  

Effects of tripterygium wilfordii polyglyco-sidium on intraocular inflammatory reaction after intraocular lens implantation

作　　者：周朝晖[1,2] 何守志[1,2] 梁延杰[1,2] 

机构地区：[1]解放军第三○四医院眼科 [2]解放军总医院眼科

出　　处：《中华眼科杂志》1998年第5期332-335,共4页Chinese Journal of Ophthalmology

摘　　要：目的动态观察雷公藤多甙对人工晶体植入术后眼内炎症反应的影响，估价雷公藤多甙的临床治疗效果及其抗炎作用的机制。方法１２０例老年性白内障随机分为２组，施行白内障囊外摘除及后房型人工晶体植入术。１组为雷公藤多甙治疗组；２组为激素治疗组。术后１、３、７及１４天定量观察前房水混浊、人工晶体表面沉着物和纤维蛋白反应。结果雷公藤多甙治疗组术后第１、３、７及１４天房水混浊、人工晶体表面沉着物和纤维蛋白反应低于激素治疗组（Ｐ＜０．０５）。结论雷公藤多甙能降低人工晶体植入术后眼前节炎症反应，雷公藤多甙治疗优于激素治疗。Objective The effects of tripterygium wilfordii polyglyco-sidium (TWP) on intraocular inflammatory reaction after extracapsular cataract extraction and intraocular lens (IOL) implantation were studied. Methods 120 cases with senile cataract were divided into two groups: (1)Patients received TWP after IOL implantation; (2) patients received prednisone after IOL implantation.The slit-lamp was used to observe inflammatory cells and fibrinous exudate in the aqueous humor and cellular deposits on IOL on the 1st,3rd,7th and 14th postoperative days.Results The study indicated that on the 1st,3rd,7th and 14th postoperative days the inflammatory cells and fibrinous exudate in the aqueous humor and cellular deposits on IOL were significantly lower in TWP-treated group than that in steroid-treated group (P<0.05).Conclusions TWP is effective in reducing postoperative anterior ocular inflammation after extracapsular cataract extraction and IOL implantation. The TWP is more effective than the steroid in suppressing postoperative intraocular inflammatory reaction.

关 键 词：雷公藤 人工晶体植入术 手术后 眼内炎 

分 类 号：R779.66[医药卫生—眼科] R771.05[医药卫生—临床医学]