半乳糖性白内障晶体上皮细胞游离钙的实验研究  

The experimental research of free calcium of the lens epithelial cells in galactose cataract

作　　者：王凤翔[1] 何守志[1] 李楠[1] 

机构地区：[1]解放军总医院眼科

出　　处：《中华眼科杂志》1998年第5期352-354,共3页Chinese Journal of Ophthalmology

摘　　要：目的研究半乳糖性白内障晶体上皮细胞中游离钙浓度变化规律。方法给２８天鼠龄的Ｗｉｓｔａｒ大白鼠投喂５０％的半乳糖饮食复制白内障模型后，分别于给药后第１，３，７，１０，１４及１９天测量晶体上皮细胞中游离钙的浓度。结果半乳糖性白内障各时期晶体上皮细胞中游离钙的浓度均明显升高，第１０天游离钙浓度最高，是正常对照组的４～５倍。结论半乳糖性白内障晶体上皮细胞中游离钙的浓度升高，各期上升的程度不同，以皮质混浊期升高幅度最大。Objective To study the changes of free calcium in the lens epithelial cells (LECs) of galactose cataract. Methods Wistar rats, 28 days old, were fed with 50% galactose forage to form cataract models. Then the concentration of free calcium of LECs was measured at the 1st, 3rd, 7th, 10th, 14th, 19th days after the galactose diet was given. Result The concentrations of free calcium in LECs of galactose cataract increased apparently and reached the maximum at the 10th day after galactose diet. The maximum was 4～ 5 times higher than that of the normal group. Conclusion The calcium concentration of LECs in galactose cataract increases but the degrees at different phases are not the same. The maximal concentration is at the phase when the cortex is opacified.

关 键 词：半乳糖 白内障 钙 晶体 上皮细胞 

分 类 号：R776.1[医药卫生—眼科]