低强度血管内激光照射降低恶性肿瘤患者化疗期间免疫抑制的临床观察  

THE CLINICAL OBSERVATION OF ILLLI REDUCED THE IMMUNITY SUPPRESSION OF TUMOR PATIENTS DURING CHEMOTHERAPY

作　　者：黄卓正[1] 李志坤[1] 欧盛秋 曾爱屏 蒙志斌 

机构地区：[1]广西医科大学附属肿瘤医院

出　　处：《广西医科大学学报》1998年第3期82-82,共1页Journal of Guangxi Medical University

摘　　要：目的：观察低强度血管内激光照射（ＩＬＬＬＩ）对恶性肿瘤患者化疗期间免疫功能的影响。方法：观察恶性肿瘤患者化疗期间辅以ＩＬＬＬＩ治疗，与同期未行ＩＬＬＬＩ的对照组患者血清中白细胞介素２受体（ｓＩＬ－２Ｒ）水平的变化。结果：化疗加ＩＬＬＬＩ的实验组化疗后３７．５％患者（９／２４例）ｓＩＬ－２Ｒ水平下降，化疗前后均值分别为５０３×１０３ＩＵ／Ｌ和５５８×１０３ＩＵ／Ｌ。对照组化疗后１００％患者（２４／２４例）ｓＩＬ－２Ｒ水平上升，化疗前后均值分别为４９３×１０３ＩＵ／Ｌ和７４４×１０３ＩＵ／Ｌ。经统计学处理，实验组化疗前后比较ｔ值为１．２３１，Ｐ＞０．０５；对照组化疗前后比较ｔ值为１２．１７７，Ｐ＜０．００１。两组间比较化疗前ｔ值为０．１６１，Ｐ＞０．０５；化疗后ｔ值为２．８３０，Ｐ＜０．０１。结论：恶性肿瘤患者化疗期同时辅以ＩＬＬＬＩ治疗，可不同程度地降低患者ｓＩＬ－２Ｒ的水平，从而缓解化疗药物对恶性肿瘤患者的免疫抑制。Objective: To observe the clinical effect of ILLLI on the immunity suppression Methods: Twenty-four cases of malignant tumor were treated with chemotherapy and intravascvlar low level laser irradiation (ILLLI), and other 24 cases treated only with chemotherapy without ILLLI used as control The sIL 2R Level between this two groups was compared Results :The sIL 2R level was reduced in 9 of 24(37 5%) patients treated with cbemotherapy and ILLLI, and the sIL 2R values before and after chemotherapy were 503×10 3IU/L and 558×10 3IU/L respectively (P>0 05) However, the level of sIL 2R after chemotherapy was significantly higher than that before chemotherapy in the control (744×10 3IU/L vs 493×10 3IU/L, P<0 001) Between ILLLI treatment patients and the control, Student's t-test for the sIL 2R was 0 161 (P>0 05) before chemotherapy, whereas Student's t test was 2 830 (P<0 01) after chemotherapy Conclusion:ILLLI may reduce the increase in the sIL 2R level during chemotherapy, therefore it may reduce the immunity suppression of tumor patients during chemotherapy

关 键 词：恶性肿瘤 药物疗法 激光疗法 免疫功能 

分 类 号：R730.5[医药卫生—肿瘤]