髓系来源的抑制性细胞在肿瘤进展过程中的研究  

Progress of the relationship between myeloid derived suppressor cells and tumor progression

作　　者：沈春[1] 任秀宝[1] 

机构地区：[1]天津医科大学附属肿瘤医院生物治疗科,300060

出　　处：《国际免疫学杂志》2009年第5期400-403,共4页International Journal of Immunology

基　　金：天津市科技创新专项资金项目（06FZZDSF01500）

摘　　要：进展性肿瘤显著的特性是逃避机体免疫系统的监视、躲避免疫系统的杀伤、抑制自体免疫系统。肿瘤在进展过程中一群髓系来源的抑制性细胞（MDSC）在肿瘤微环境、引流区淋巴结大量聚集，其能够促进肿瘤的发展同时抑制机体的免疫作用。其机制概括为：髓系细胞向正常树突状细胞或巨噬细胞的分化受阻，分泌促进肿瘤生长的细胞因子，参与肿瘤血管的形成，诱导调节性T淋巴细胞（Treg）的产生，从而抑制了T淋巴细胞的抗肿瘤作用。Progressive tumors acquire the ability to escape from immune recognition and eytotoxicity. These tumors can suppress host immune system as well. Recent studies have demonstrated that tumors have the ability to accumulate myeloid derived suppressor cells（MDSC） at the tumor site and drain lymphoid organs. These cells favor tumor development and suppress immune system through following mechanisms, such as inhibiting differentiation of immuno-competent dendritic cell （DC） and macrophages, secreting cytokines essential for tumor growth, participating in tumor angiogenesis , expanding Tregs from a preexisting population of natural Tregs, which exert profound inhibitory activity on both tumor-specific and nonspecific T lymphocytes.

关 键 词：髓系来源的抑制性细胞 免疫抑制 调节性T细胞 肿瘤血管形成 

分 类 号：R730.3[医药卫生—肿瘤]