白细胞介素-1O启动子区域627位基因多态性与乙型肝炎肝硬化的关系  

Association between polymorphism at position 627 of interleukin-10 promoter and liver cirrhosis after hepatitis B infection

作　　者：范顺富[1] 杨益大[2] 

机构地区：[1]浙江省金华市中心医院感染科,321000 [2]浙江大学医学院附属第一医院传染病诊治国家重点实验室

出　　处：《中华临床感染病杂志》2009年第4期205-208,共4页Chinese Journal of Clinical Infectious Diseases

摘　　要：目的研究IL-10启动子区627位点多态性与乙型肝炎肝硬化的关系。方法应用聚合酶链反应-限制性片段长度多态性（PCR—PFLP）等技术检测220例乙型肝炎肝硬化患者及200名健康对照者IL—10启动子627位等位基因及基因型频率的分布情况，分析其与肝硬化发病风险的相关性。结果IL—10启动子627位点AA和CA基因型及等位基因A在乙型肝炎肝硬化中的分布明显高于对照组（x^2=7．46、5．72和13．78，P值〈0．01或0．05）。结论IL-10启动子627位点基因多态性与乙型肝炎肝硬化相关。Objective To investigate the association between the polymorphism at position 627 in IL-10 promoter and the prevalence of HBV related cirrhosis. Methods PCR-restriction fragment length polymorphism （PCR-PFLP） was performed to detect polymorphisms of IL-10 promoter-627 in 220 patients with HBV related cirrhosis and 200 healthy controls. The contribution of polymorphism at position 627 to HBV related cirrhosis was calculated. Results The frequeney of AA and CA genotypes and A allele at position 627 of IL-10 promoter region were significantly higher in patients with HBV-related cirrhosis than that of healthy controls （X^2 = 7.46,5.72,13.78,P 〈 0.01 or P 〈 0.05 ）. Conclusion There are significant association between the polymorphism at position 627 in the IL-10 promoter region and the prevalence of HBV related cirrhosis.

关 键 词：肝炎 乙型 肝硬化 白细胞介素-10启动子 627位点 基因多态性 

分 类 号：R575[医药卫生—消化系统] R51[医药卫生—内科学]