成人急性淋巴细胞白血病的MIC分型与临床预后分析  

MIC Classification and its Clinical and Prognostic Analysis of Acute Lymphocytic Leukemia

作　　者：叶琇锦[1] 林茂芳[1] 周国华 谢万灼[1] 梁毅[1] 陈志妹 金洁[1] 

机构地区：[1]浙江医科大学附属第一医院血液病科 [2]浙江安吉县第一医院

出　　处：《浙江医科大学学报》1998年第4期151-154,共4页

摘　　要：分析成人急性淋巴细胞白血病（ALL）的MIC：分型与临床及预后的关系。方法：40例ALL。患者按常规骨髓涂片及细胞化学染色进行形态学分析，并用单克隆抗体间接免疫荧光法检测细胞免疫表型，用R显带技术分析13例的细胞遗传学。结果：FAB分型ALL-LI型3例，L2型35例，L3型2例。细胞免疫表型符合T细胞系ALL13例（伴髓系表达2例），B细胞系ALL21例（伴髓系表达4例），T／B细胞系共同表达ALL5例（伴髓系表达1例），未分化型急性白血病1例。13例中有8例核型异常。结论：ALL患者形态学检查结合免疫学和细胞遗传学综合分析，有利于明确白血病细胞克隆的来源，有利于估计预后，并指导治疗。Objective: To analyse the relationship of morphology-immunology-cytogene (MIC) typing classification of adult acute leukemia (ALL ) to its clinical significance and prognosis. Methods: The morphology of 40ALL. patients was examined by conventional bone marrow smearing and cytochemistry staining, and their immunophenotype by indirect imrnunofluoresence assay with monoclonal antibodies (McAbs). The cytogenetics of13 cases was analyzed by R-banding technique. Results: There were 3 cases with ALL-L1, 35 cases with ALL-L2 and 2 cases with ALL-L3 according to FAB classification. It was found that T-cell antigens were expressedin 13 cases with myeloid antigens in 2 cases, B-cell antigens were co-expressed in 21 cases with myeloid antigensin 4 cases and T/B cell antigens were co-expressed in 5 cases with myeloid antigens in I case. one case with undifferentiated acute leukemia was found. Abnormal chromosome karyotypes of & cases were found among 13 cases. Conclusion: The comprehensive analysis of MIC and the clinical features of ALL is of value in the prognosisand treatment of the disease.

关 键 词：急性 淋巴细胞 白血病 MIC分型 预后 

分 类 号：R733.71[医药卫生—肿瘤]