实体瘤多药耐药性与P-gp和p53表达的关系  

THE RELATIONSHIP BETWEEN MULTIDRUG RESISTANCE OF SOLID TUMORS AND THE EXPRESSION OF P-gp AND p53

作　　者：朱静娟[1] 沈方臻[1] 陈维刚[1] 刘砚玉 雷炜[1] 

机构地区：[1]青岛医学院附属医院肿瘤科

出　　处：《青岛医学院学报》1998年第3期175-177,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨４种常见实体瘤多药耐药性与Ｐ－糖蛋白（Ｐ－ｇｐ）及ｐ５３表达的关系。②方法采用ＭＴＴ比色法检测胃癌、大肠癌、乳癌、肺癌对１４种化疗药的耐药性；用免疫组化方法检测同一标本Ｐ－ｇｐ，ｐ５３的表达。③结果１０９例标本中多药耐药者５１例，疏水性药物耐药者５９例。各肿瘤Ｐ－ｇｐ阳性表达者共４０例，ｐ５３阳性表达者共６３例。乳癌疏水性耐药组Ｐ－ｇｐ表达率为５７．１％，对照组表达率为９．０％；大肠癌多药物耐药组ｐ５３表达率为１００％，敏感组表达率为５０％．④结论Ｐ－ｇｐ阳性表达可反映乳癌的疏水性耐药，ｐ５３阳性表达是大肠癌多药耐药的标志之一。Objective To investigate the relationship between the multidrug resistance and the expression of p-glycoprotein(P-gp) and p53 protein in 4 commonly seen solid tumors.MethodsSensitivities to 14 anticancer drugs were examined in gastric cancer, colorectal cancer, lung cancer and breast cancer with MTT assay and the expression of Pgp and p53 was detected by using immunohistochemistry.ResultsOf the 109 cases, 51 exhibited pleiotropic drug resistance and 59 cases had hydrophobic drug resistance,40 patients showed positive expression of P-gp and 63 patients were p53 positive.The P-gp positive rate of breast cancer patients with hydrophobic drug resistance was 57.1% and the control group was 9.0%.The expression rate of p53 in pleiotropic chemoresistance group of colorectal cancers was 100% and the control group was 50%.ConclusionThe hydrophobic drug resistance of breast cancer was associated with P-gp expression. p53 expression was the marker of pleiotropic drug resistance of colorectal cancer.

关 键 词：肿瘤 P-GP P53基因 多药耐药性 

分 类 号：R730.231[医药卫生—肿瘤] R730.53[医药卫生—临床医学]