电刺激腹侧被盖区及损伤前脑内侧束对后侧伏核神经元电活动的影响  

THE EFFECT OF ELECTRICAL STIMULATION ON VENTRAL TEGMENTAL AREA AND MEDIAL FOREBRAIN BUNDLE LESION ON THE FIRING OF NEURONS IN THE POSTERIOR NUCLEUS ACCUMBENS

作　　者：孙朝晖[1] 谢俊霞[1] 蒋正尧[1] 唐明[1] 

机构地区：[1]青岛医学院生理学教研室

出　　处：《青岛医学院学报》1998年第3期180-182,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：山东省自然科学青年基金

摘　　要：目的探讨电刺激腹侧被盖区（ＶＴＡ）及损伤前脑内侧束（ＭＦＢ）对后侧伏核（ＰＮＡ）神经元电活动的影响。②方法应用电生理学方法，记录了正常大鼠、帕金森病（ＰＤ）大鼠模型健侧、６－羟基多巴胺（６－ＯＨＤＡ）损毁ＭＦＢ侧ＰＮＡ神经元的自发放电，同时观察电刺激ＶＴＡ对ＰＮＡ神经元放电的影响。③结果电刺激ＶＴＡ后神经元多数呈抑制反应（ｔ＝２．１７，Ｐ＜０．０５）；正常大鼠自发单放电频率较ＰＤ大鼠模型损毁侧放电频率低（ｑ＝３．４９，Ｐ＜０．０５），而与ＰＤ大鼠模型健侧ＰＮＡ神经元放电频率相比较，差别无显著意义（ｑ＝２．８９，Ｐ＞０．０５）。Objective To study the effect of electrical stimulation on the ventral tegmental area and medial forebrain bundle(MFB) lesion on the firing of neurons in the posterior nucleus accumbens. Methods Electrophysiological technique was used to investigate the neuronal firing of the posterior nucleus accumbens(PNA) in normal intact and Parkinson's disease(PD) and 6-hydroxy-dopamine(6-OHDA) injured MFB rats. The change of firing rate of the ventral tegmental area after electrical stimulation(VTA) were observed. Results Most of the neurons exhibited inhibitory response to electrical stimulation of the VTA(t=2.17,P<0.05). The firing rate in normal rats was less than that of 6hydroxydopamine(6-OHDA) injured MFB sides (q=3.49,P<0.05), but almost similar to that of nonlesioned sides in PD rats(q=2.89,P> 0.05). Conclusion The results demonstrated that the neuronal activity of PNA received inhibitory regulation of VTA through MFB. 

关 键 词：后侧伏核 神经元 电刺激 震颤性麻痹 大鼠 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R338.8[医药卫生—临床医学]