急性脑梗塞早期溶栓疗法的疗效观察  

STUDY ON THE EFFECT OF EARLY THROMBOLYTIC THERAPY IN ACUTE CEREBRAL INFARCTION

作　　者：杜正强[1,2] 王平 赵丽丽[1,2] 孙冬 刘玉霞[1,2] 王介之[1,2] 

机构地区：[1]青岛市市立医院神经科 [2]青岛医学院计算机学教研室

出　　处：《青岛医学院学报》1998年第3期194-195,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨急性脑梗塞的早期溶栓疗效。②方法随机设置对照组与治疗组，对照组用甘露醇、低分子右旋糖酐、钙离子拮抗剂等常规治疗；治疗组在常规治疗基础上，加用尿激酶（ＵＫ）１５０～４００万单位静脉滴注溶栓治疗，部分病人溶栓治疗后加用肝素（总量２００ｍｇ）抗凝治疗４８ｈ，治疗前后行ＥＳＳ评分，比较溶栓的疗效及并发症，找出最佳ＵＫ剂量。③结果治疗组与对照组治疗２ｈ后ＥＳＳ评分、治愈率、病死率比较，差异均有显著性（ｔ＝３．３９，χ２＝１３．０８，５．６３，Ｐ＜０．０５，０．０１）。Objective To study the effect of early thrombolytic therapy in acute cerebral infarction. Methods 46 patients with acute cerebral infarction were divided into two groups: control group and urokinase group. In control group, general therapy such as mannitol, low molecular dextran, calcium entry blocker etc. were administered by intravenous infusion .In urokinase group, urokinase (150×104—400×104u) was administered by intravenous infusion for 60 or 120 minutes on the basis of general therapy. Heparin (200mg) was administered in some of the patients treated with urokinase for 48 hours. ESS evaluation on the effect of thrombolysis, complication between baseline and postinfusion were made in the two groups so as to find out the most safe and effective dose of urokinase. Results A comparison between control group and urokinase group showed significant differences in ESS evaluation 2h after treatment(t=3.39,P<0.01), mortality (χ2=5.63,P<0.05), recovery rate(χ2=13.08, P<0.01).  Conclusion Early thrombolytic therapy was very effective in acute cerebral infarction.

关 键 词：脑梗塞 抗凝药 溶栓疗法 早期治疗 疗效 

分 类 号：R743.330.5[医药卫生—神经病学与精神病学]