生长抑素和生长激素联合防治急性坏死性胰腺炎肺损伤的研究  

Prevention and treatment of lung injury in acute necrotizing pancreatitis with somastostatin and growth hormone.

作　　者：倪泉兴[1] 张妞[1] 张群华[1] 张延龄[1] 向阳[1] 郑颂国 罗建民 

机构地区：[1]上海医科大学附属华山医院外科,200040

出　　处：《中华实验外科杂志》1998年第5期404-406,共3页Chinese Journal of Experimental Surgery

摘　　要：目的探讨生长激素和生长抑素对急性坏死性胰腺炎(ANP)并发肺损伤的防治作用。方法逆行胰胆管注射3.5%牛磺胆酸钠建立ANP动物模型,用ELISA方法测血液中TNF α水平和免疫组化法观察肺组织中TNF α水平。结果生长抑素和生长激素联合治疗可抑制炎症因子的过度生成,并使肺组织TNF α表达接近正常。结论生长抑素和生长激素联合治疗对ANP早期并发的肺损伤有防治作用。Objective To investigate the provention and treatment of lung injury in acute necrotizing pancreantis (ANP) with somastostatin and growth hormone. Methods ANP animal model was developed in adult male mice by retrograde injection of 3.5% sodium taurocholate 2.5 ml/kg in pancreatic duct. Serum TNF a level was determined by ELISA and the expression of TNF α in lung measured by immunohistochemistry. Results The inflammatory mediators were positively correlated with the severity of ANP. For the combined use of somastostatin and growth hormone, the levels of the inflammatory mediators were markedly decreased and the expression TNF α in lung was almost normal. Conclusion The combined use of somastostatin and growth hormone might prevent and treat the associated lung injury in the early stage of ANP.

关 键 词：胰腺炎 TNFΑ 肺损伤 生长抑素 生长激素 

分 类 号：R657.510.6[医药卫生—外科学] R563.05[医药卫生—临床医学]