沙土鼠缺血再灌注时红细胞β-内啡呔对红细胞免疫粘附功能调控的研究  

A study of the regulation of RBCβ-EP to RCIA during cerebral ischemia reperfusion in gerbil.

作　　者：丁素菊[1,2] 郑惠民[1,2] 侯晓军 郭峰[1,2] 王成海 时善全[1,2] 

机构地区：[1]上海第二军医大学长海医院神经内科 [2]江苏省邳州市中医院神经内科

出　　处：《中风与神经疾病杂志》1998年第4期201-202,共2页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨沙土鼠缺血再灌注时红细胞β－内啡呔（β－ｅｎｄｏｒｐｈｉｎβ－ＥＰ）对红细胞免疫粘附功能（ＲｅｄｃｅｌｉｍｍｕｎｅａｄｈｅｒｅｎｃｅＲＣＩＡ）有否调控作用。方法采用蒙古种沙土鼠缺血再灌注模型分别测定ＲＣＩＡ以及红细胞β－ＥＰ（ＲＢＣ－β－ＥＰ）含量，观察两者相互关系，进一步探讨其发生机制。结果显示单纯缺血时ＲＢＣ－β－ＥＰ含量轻度升高，但ＲＣＩＡ降低不明显；而再灌注时随红细胞β－ＥＰ含量明显升高，ＲＣＩＡ功能降低明显。结论在缺血再灌注时，一定浓度的ＲＢＣ－β－ＥＰ对红细胞免疫有促进作用，而高浓度时则有抑制作用。Objective To study the effects of the RBCβ-EP regulated red cell immune adherence (RCIA) during cerebral ischemia reperfusion in gerbil.Methods RCIA and RBCβ-EP were determined respectively by means ofgerbil.Rusults RBCβ-EP increased slightly while RCIA didn't change markly during cerebral ischemia,with RBCβ-EP significantly increasing,RCIA decreased obviously during cerebral ischemiareperfusion.Conclusion RBCβ-EP promoted the function of RCIA,excessive amounts of β-EP inhibited the function of RCIA.The suggests that blocking β-EP production can contributes to improve the function of RCIA.

关 键 词：Β-EP 红细胞 免疫粘附功能 沙土鼠 脑缺血 

分 类 号：R743.31[医药卫生—神经病学与精神病学]