高度近视黄斑区脉络膜新生血管的相关危险因素研究  

Studies on the risk factors associated with macula choroidal neovascularization in high myopia

作　　者：李学喜[1] 林巧雅[1] 黄雪丽[1] 

机构地区：[1]解放军第180医院眼科,福建泉州362000

出　　处：《解放军医学杂志》2009年第9期1120-1121,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：目的了解高度近视患者黄斑区脉络膜新生血管(CNV)的发生率,并探讨其发病的相关危险因素。方法收集2008年3月-2009年6月门诊的56例(112只眼)高度近视患者,对其行眼部A超、B超、屈光度检查和光学相干断层成像术(OCT)检查,观察有无CNV及CNV的生长特征,记录患者基本情况、主要症状及黄斑区病理性改变。分析影响CNV发生的相关危险因素。结果56例(112只眼)高度近视患者黄斑区CNV发生率为14.29%(16/112)。性别(r=-0.015,P=0.879)与CNV的发生无关;年龄(r=0.629,P=0.000)、屈光度(r=0.725,P=0.000)、眼轴(r=0.236,P=0.013)、后巩膜葡萄肿(r=0.344,P=0.000)、后极部大片视网膜脉络膜萎缩(r=0.421,P=0.000)、漆裂纹(r=0.421,P=0.000)和Fuchs斑(r=0.519,P=0.000)与CNV的发生显著相关。结论高度近视患者黄斑区CNV的发生率高,后巩膜葡萄肿、后极部大片视网膜脉络膜萎缩、漆裂纹、Fuchs斑、年龄、屈光度和眼轴是高度近视黄斑区CNV形成的相关危险因素。Objective To investigate the prevalence of macula choroidal neovascularization （CNV） in high myopia patients and the associated risk factors. Methods Fifty-six outpatients （112 eyes） with high myopia were medically examined from Mar. 2008 to Jun. 2009. The inspection items, including A scan, B scan, diopter and optical coherence tomography （OCT）, were carried out to check whether CNV existed and its growth fashion. The patients basic status, main symptoms and the pathologic change in macula were recorded. Results The prevalence of CNV in the 56 outpatients （112 eyes） was 14. 3%. Gender showed no correlation with CNV （r=- 0. 015, P=0. 879）, while age （r=0. 629, P=0. 000）, diopter （r=0. 725, P=0. 000）, axial length （r=0. 236, P=0. 013）, posterior scleral staphyloma （r= 0. 344, P= 0. 000）, atrophy of choroid and retina in posterior pole （ r= 0. 421, P= 0. 000）, lacquer crack （r= 0. 421, P=0. 000） and Fuchs spot （r=0. 519, P=0. 000） were significantly correlated with the prevalence of CNV. Conclusions CNV may highly occurred in the patients with high myopia. Posterior scleral staphyloma, atrophy of chomid and retina in posterior pole, lacquer crack, Fuchs spot, age, axial length and diopter seem to be the risk factors for the occurence of CNV.

关 键 词：近视 脉络膜新生血管化 体层摄影术 光学相干 

分 类 号：R774.5[医药卫生—眼科]