大豆异黄酮对去卵巢大鼠血糖及血脂影响  

Effect of isoflavone in obesity prevention in overiectomied rats

作　　者：张云波[1] 那晓琳[1] 李丽娜[1] 赵新宇[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院环境与卫生学教研室,哈尔滨150086

出　　处：《中国公共卫生》2009年第9期1127-1128,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金(30671755);黑龙江省卫生厅项目(2006-300)

摘　　要：目的观察大豆异黄酮对去卵巢大鼠体重以及对血脂、血糖的影响。方法清洁级8周龄雌性SD大鼠42只,随机分为6组。手术后均给予高脂饲料喂养诱导肥胖,实验组同时进行受试物灌胃。实验第4周末采血,摘取各脏器称重,进行血糖、血脂水平的检测。结果与去卵巢对照组(OVX)相比,大豆异黄酮中剂量组(M-SI)、高剂量组(H-SI)和雌激素组(EC)大鼠体重分别降低了5.6%,8.5%,12.9%,差异均有统计学意义(P<0.05),而大豆异黄酮低剂量组(L-SI)大鼠体重无明显变化。肾周脂肪和宫旁脂肪重量变化与体重变化相同。高剂量大豆异黄酮可使子宫脏/体比值增加了92.5%(P=0.026),而对其他脏器的脏/体比值无明显影响;M-SI、H-SI组大鼠总胆固醇(TC)、甘油三酯(TG)水平明显降低,高密度脂蛋白胆固醇(HDL-C)水平明显升高;对血糖水平的升高也有较明显的抑制作用(P<0.05)。结论大豆异黄酮能够预防由高脂饲料诱导的去卵巢大鼠的肥胖,减少腹部脂肪沉积,并且具有改善血脂、血糖的作用。Objective To investigate the beneficial effects of isoflavone on obesity,blood lipids and blood glucose in overiectomied（OVX） rats. Methods Female 8-week-old SD rats were randomly assigned to 6 groups. There were shamoperated control group（ SHAM）, ovariectomied control group（ OVX）, OVX with low-, middle-, and high-isoflavone groups （L-SI,M-SI,H-SI） ,and OVX with estrogen group（EC）, All animals were allowed freely to high fat diet and water for 4 weeks. Four weeks later, all rats were killed. Fat pad and internal organs were taken out and weighted. Blood lipids and blood glucose were examined by kits. Results Compared with OVX control,body weight,perirenal and parametrial fat weight were reduced in isoflavone groups（ P 〈 0. 05 ）. Uterus weight of high isoflavone group increased lightly（ P = 0. 026） but other organs were not affected. Serum total cholesterol, triglyceride levels were reduced and high density lipid-cholesterol level was in- creased in isoflavone groups. Blood glucose was decreased significandy in middle-and-high isoflavone group. Conclusion Isoflavone could reduce the body weight induced by OVX,decrease abdominal fat pad deposition,and improve blood fat and blood glucose.

关 键 词：大豆异黄酮 去卵巢大鼠 肥胖 血脂 血糖 

分 类 号：R151.3[医药卫生—营养与食品卫生学] R681[医药卫生—公共卫生与预防医学]