高白细胞性急性白血病首次化疗方案及剂量与预后的关系  

Relationship between initial chemotherapy and prognosis in patients with hyperleukocytic acute leukemia

作　　者：谢德荣[1] 姚和瑞[1] 曾宪平[1] 李玉巧 张惠宜[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院肿瘤科,510120

出　　处：《新医学》1998年第10期516-517,共2页Journal of New Medicine

摘　　要：目的 :探讨高白细胞性急性白血病首次化疗方案、化疗剂量与预后的关系。方法 :分为早期病死组 2 3例 ,非早期病死组 39例 ,对两组进行回顾性对照分析。结果 :化疗剂量、化疗方案是早期病死重要的影响因素。常规剂量化疗 ,发生早期病死的相对危险度约为小剂量化疗的 2 0倍 ;含有蒽环类抗生素的化疗方案化疗 ,发生早期病死的相对危险度约为其它化疗方案化疗的 2倍。结论 :首次化疗避免过于强烈 ,有助于降低早期病死率。Objective:To study the relationship between initial chemotherapy and prognosis in patients with hyperleukocytic acute leukemia(HAL).Methods:62 cases of HAL were divided into two groups,23 cases in early death(ED)group,39 in Non-ED gorup.Restrospective analysis and control study were used.Results:Multifactors Logistic analysis indicated that the dose and drug regiments of initial chemotherapy were the most important factors influenced ED.The relative risk(RR)of ED patients treated with traditional dose of chemotherapy was about 20 times as more as that treated with low dose.while the RR of ED patients treated with anthracycline antibiotics was about twice as more as that with other regiments.Conclusion:Avoiding too intensive initial chemotherapy may be good for lowing down the rate of ED in patients with HAL.

关 键 词：白血病 急性 高白细胞性 药物疗法 化疗方案 

分 类 号：R733.710.5[医药卫生—肿瘤]