伽玛刀治疗颅咽管瘤疗效观察  

Effect of gamma knife surgery on treatment of craniopharyngiomas

作　　者：伍炜[1] 罗光华[1] 应克明[1] 黄本生[2] 袁同方 

机构地区：[1]淮南朝阳医院伽玛刀治疗中心,安徽省淮南232007 [2]淮南朝阳医院神经外科,安徽省淮南232007

出　　处：《中国基层医药》2009年第8期1403-1404,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨伽玛刀治疗颅咽管瘤的疗效及并发症。方法伽玛刀治疗颅咽管瘤41例，其中7例囊实混合性肿瘤行立体定向穿刺手术，6例伽玛刀治疗前行分流手术；中心剂量17．1～40Gy，采用30％～50％等剂量曲线，周边剂量6～14Gy，视神经和视束受照剂量小于10Gy。结果29例获随访，随访时间6～100个月，好转16例，稳定6例，2例分别于伽玛刀术后1年、3年复发行开颅手术，5例分别于伽玛刀术后1～3年病情恶化死亡。肿瘤控制率为75．9％（22／29）。结论伽玛刀治疗对大多数实体性颅咽管瘤是敏感的，必要时可行立体定向穿刺手术结合伽玛刀治疗。Objective To evaluate the adaption,effectiveness,dose,complication of the treatment for craniopharygiomas with gamma knife surgery. Methods Gamma knife surgery was performed in 41 patients. Patients with mixed solid and cystic tumors were treated with stereotaxic aspiration while six cases were treated with divergence surgery prior to gamma knife therapy. The central dose ranges from 17. 1 -40 Gy（29. 6Gy in average）. The patients were treated at 30% - 50% equal dose curve with 6 - 14Gy of tumormargin dose （9.5 Gy in average）. The exposure dose of the optic nerve and optic tract is less than 10Gy. Results Of twenty-nine patients who were followed up from 6 to 100 months, sixteen had disappeared or decreased tumor, six had unchanged, two was performed craniotomy one year or three years after gamma knife surgery, and the remaining five were dead one year to three years. The tumor control rate was 75. 9% （22/29）. Conclusion The treatment of stereotaxic radiation with single and high dose is sensitive to most of the solid craniopharyngioma, and the treatment of stereotaxic resection combined with gamma knife surgery may be feasible for the recurrent mixed solid and cystic craniopharyngioma.

关 键 词：颅咽管瘤 伽玛刀 放射外科手术 

分 类 号：R73[医药卫生—肿瘤]