广西肝细胞癌与丙型肝炎病毒的相关性  

TherelationshipbetweenhepatocelularcarcinomaandhepatitisCvirusinfectioninGuangxi,ChinaDengZhuolin,MaYun,LiDefu,etal.GuangxiMedicalUniversity,Nanning530021 Abstract ObjectiveTostudythesignificanceofHCVinfectionasariskfactorforhepatocelularcarcinoma(HCC)i

作　　者：邓卓霖[1,2] 马韵[1,2] 李德富[1,2] 郎淑慧[1,2] 丁志敏[1,2] 阮伶[1,2] 

机构地区：[1]广西医科大学病理教研室 [2]中国药品生物制品检定所

出　　处：《中华肿瘤杂志》1998年第5期354-356,共3页Chinese Journal of Oncology

摘　　要：目的研究广西肝癌高、中、低危区的癌及癌旁肝组织中丙型肝炎病毒（ＨＣＶ）的表达，探讨ＨＣＶ在广西肝细胞癌（ＨＣＣ）病因中的地位。方法用ＨＣＶ的Ｃ区、ＮＳ３和ＮＳ４区３种单克隆抗体及抗ＨＢｓＡｇ抗体进行检测。免疫组化染色用ＳＰ法。结果ＨＣＣ高、中、低危区肝癌中ＨＣＶ阳性率依次为３８．１％（２４／６３）、３７．１％（２３／６２）和３９．０％（３０／７７）；ＨＢｓＡｇ阳性率依次为８４．１％、８３．８％和８４．４％。ＨＣＣ中ＨＣＶ感染的总数为７７／２０２（３８．１％），乙型肝炎病毒感染总数为１７０／２０２（８４．２％）。结论ＨＣＣ经常伴随乙型肝炎病毒（ＨＢＶ）感染，但ＨＣＶ可见于１／３的ＨＣＣ。在广西肝癌高、中、低发地区，ＨＢＶ与ＨＣＶ感染情况无明显差别。Objective To study the significance of HCV infection as a risk factor for hepatocellular carcinoma (HCC) in Guangxi. Methods Monoclonal antibodies against the core, NS3 and NS4 region of HCV, and anti HBsAg antibody were used for immunohistochemical staining. Results The frequency of HCV infection from regions with high, intermediate and low prevalence of HCC was 24/63(38.1%), 23/62 (37.1%) and 30/77 (39.0%), respectively, while that of HBsAg was 84.1%, 83.8% and 84.4%, respectively. The overall positive rate of HCV infection was 77/202 (38.1%), and of HBV infection was 170/202 (84.2%). Conclusion While HBV infection frequently accompanies HCC, HCV infection is present in more than 1/3 of HCC. This is generally the case regardless of geographical difference in HCC prevalence.

关 键 词：肝肿瘤 肝细胞癌 丙型肝炎病毒 免疫组织化学 

分 类 号：R735.702[医药卫生—肿瘤]