肝动脉栓塞化疗联合CT导向下碘油乙醇注射治疗原发性肝细胞癌疗效观察  

Transcatheter arterial chemo embolization combined with CT guided percutaneous intratumoral injection of lipiodol ethanol for the treatment of primary hepatocellular carcinoma

作　　者：吴沛宏[1,2,3] 李立[1,2,3] 张益民 张福君[1,2,3] 黄金华 郑列[1,2,3] 谢琦 

机构地区：[1]中山医科大学肿瘤医院影像介入科 [2]广州市第一人民医院 [3]河北省邯郸市医学专科学校

出　　处：《中华肿瘤杂志》1998年第5期391-393,共3页Chinese Journal of Oncology

摘　　要：目的探讨原发性肝细胞癌肝动脉栓塞化疗（ＴＡＣＥ）联合ＣＴ导向下碘油乙醇注射的疗效。方法原发性肝细胞癌１０２例，分为两组进行治疗：（１）经导管肝动脉栓塞化疗组（ＴＡＣＥ组），５２例；（２）肝动脉栓塞化疗联合ＣＴ导向下碘油乙醇注射治疗组（联合治疗组），５０例。结果ＴＡＣＥ组１，２，３年生存率分别为６８．３％、４１．２％和２１．４％，组织学检查，仅２６．１％的病变完全坏死；联合治疗组１，２，３年生存率分别达１００．０％、８５．２％和６８．４％，组织学检查８６．４％的病变完全坏死。两组间１，２，３年生存率和肿瘤的完全坏死率差异均有显著性（Ｐ＜０．０５）。结论联合治疗效果优于单纯栓塞化疗。Objective To study the therapeutic effect of transcatheter arterial chemoembolization (TACE) combined with CT guided percutaneous intratumoral injection of lipiodol ethanol(ITLE) for primory hepatocellular carcinoma. Methods One hundred and two patients with primary hepatocellular carcinoma (PHC) were divided into two groups. In group A, 52 patients treated with TACE, and in group B, 50 patients were treated with TACE and ITLE. Results In group A 1 , 2 , and 3 year survival rate of the treated patients was 68.3%, 41.2%, and 21.4%, respectively. Histologic examination of cancer specimens obtained from hepatectomy and biopsy showed that TACE caused complete necrosis in only 26.1% of the treated cases. In contrast, in group B patients treated with TACE combined with ITLE, the 1 , 2 , and 3 year survival rate was 100%, 85.2% and 68.4%, respectively. Combination therapy resulted in complete histologic necroses in 86.4% of the treated cases. Conclusion The therapeutic effect of TACE combined with CT guided ITLE is much better than that of TACE alone.

关 键 词：肝肿瘤 药物疗法 肝细胞瘤 栓塞疗法 碘油 

分 类 号：R735.705[医药卫生—肿瘤]