LP和TP方案治疗晚期非小细胞肺癌的临床研究  

Clinical study of comparing LP and TP regimens in the treatment of advanced non-small cell lung cancer

作　　者：高建飞[1] 赵勇[1] 章必成[1] 朱宇泽[1] 饶智国[1] 刘健[1] 余丽芳[1] 杜光祖[1] 

机构地区：[1]广州军区武汉总医院肿瘤科,武汉430070

出　　处：《临床肿瘤学杂志》2009年第8期698-700,共3页Chinese Clinical Oncology

摘　　要：目的:比较紫杉醇脂质体(LEP)联合顺铂(DDP)组成的LP方案与紫杉醇(TAX)联合DDP组成的TP方案治疗晚期非小细胞肺癌(NSCLC)的疗效和毒副反应。方法:将89例晚期NSCLC患者随机分为LP组(57例)和TP组(32例),观察各组的近期及远期疗效、毒副反应和生存情况。结果:LP组和TP组的有效率分别为40.00%和38.71%,无显著性差异(P>0.05)。两组的肿瘤进展时间(TTP)分别为18周和17周,中位缓解期分别为20周和18周,中位生存期分别为35周和31周,1年生存率分别为35.09%和28.15%,均无显著性差异(P>0.05)。两组Ⅰ～Ⅱ度末梢神经炎发生率分别为19.29%和37.50%(P<0.05);Ⅰ～Ⅱ度过敏反应发生率分别为5.26%和12.50%(P<0.05);Ⅲ～Ⅳ度恶心呕吐发生率分别为5.26%和15.63%(P<0.01)。结论:LP与TP方案治疗晚期NSCLC疗效相似,但LP方案的外周神经毒性、过敏反应和恶心呕吐等毒副反应明显较低。LP方案可以作为晚期NSCLC的一线化疗方案。Objective：To evaluate the response and toxicity of liposome encapsulated paclitaxel（LEP） plus cisplatin（DDP）（LP regimen） and paclitaxel（TAX） plus DDP（TP regimen） in the treatment of advanced non-small cell lung cancer（NSCLC）.Methods：A total of 89 cases with advanced NSCLC were randomized into two groups： LP group（57 patients） and TP group（32 patients）.The response,toxicity and survival time of the two groups were compared.Results：The response rates were 40.00% and 38.71% in the LP and TP group respectively, but no significant difference was detected between them（P 〉0. 05）. The median time to progression（ITP）, median remission time, median survival time and 1 year survival rates were 18 weeks, 20 weeks, 35 weeks and 35.09% in LP group, and 17 weeks, 18 weeks, 31 weeks and 28. 15% in TP group, and no significant differences were detected between them（ P 〉 0. 05 ）. The grade Ⅰ-Ⅱ peripheral neuritis in TP group（37. 50% ） were higher than that in LP group（ 19. 29% ） significantly（P 〈0. 05）. The grade Ⅰ-Ⅱallergic reaction in TP group（ 12. 50% ） was higher than that in LP group（ 5.26% ） significantly（ P 〈 0. 05 ）. The grade Ⅲ-Ⅳnausea/vomiting in TP group（ 15.63 % ） was higher than that in LP group （5, 26% ） significantly （P 〈 0. 01 ）, too. Conclusion：The effect of LP regimen is similar to TP regimen, but peripheral neuritis, allergic reaction and nausea/vomiting in LP regimen are lower than those in TP regimen. In short, LP regimen may be the first line chemotherapy regimen of advanced NSCLC.

关 键 词：非小细胞肺癌 化学疗法 紫杉醇脂质体 紫杉醇 顺铂 

分 类 号：R734.2[医药卫生—肿瘤]