淋巴结微转移检测对结直肠癌病理分期的影响  

The Value of Lymph Node Micrometastasis Detection in Determining the Stage of Colorectal Carcinoma

作　　者：于游[1] 王灿[1] 彭力[1] 吴强[1] 韩继明[1] 李雅嘉[1] 

机构地区：[1]重庆市急救医疗中心重庆第四人民医院

出　　处：《肿瘤预防与治疗》2009年第2期165-167,共3页Journal of Cancer Control And Treatment

基　　金：重庆市卫生局科研项目资助(编号:06-2-011)

摘　　要：目的：探讨淋巴结微转移对结直肠癌患者病理分期的影响。方法：对2003年3月至2008年10月间手术切除的60例结直肠癌患者的990枚淋巴结进行常规HE染色和CK20免疫组化检查,检测结直肠癌的淋巴结转移,并对结果进行统计学分析。结果：应用HE染色法淋巴结转移检出率27.2%（269/990）,CK20免疫组化淋巴转移检测率为37.2%（368/990）,两者差异有统计学意义（P〈0.05）。99枚淋巴结检出有微转移,11例TNM分期提高,HE染色重新分期率为18.3%（11/60）。结论：CK20免疫组化的检测可以显著提高淋巴结转移的检出率,有助于更准确地进行结直肠癌的临床病理分期。Objective： To detect micrometastasis in regional lymph nodes and evaluate the significance of the new assessment of nodal status in determining pN staging of colorectal carcinoma. Methods： In addition to HE, IHC with Cytokeratin-20 was used to detect icrometastasis in 990 lymph nodes from 60 patients with colorectal carcinoma from Mar. 2003 to Oct. 2008. Results： The detection rate of HE staining was 27.2% （269/990）, and the detection rate of IHC staining was 37.2% （368/990） （ P 〈 0.05 ）. Lymph node micrometastasis was further detected in 99 nodes from 11 patients. The rate of second HE staging was 18. 3 % （11/60）. Conclusion： IHC with Cytokeratin-20 can increase the detecting of lymph node metastasis and have a significant impact on the staging system of colorectal carcinoma.

关 键 词：结直肠癌 淋巴结微转移 免疫组化 临床分期 

分 类 号：R735.34[医药卫生—肿瘤]