转化生长因子β1及其Ⅱ型受体表达与子宫内膜癌发生的关系  

The correlation between the expression of transforming growth factor β1 as well as its receptor and the genesis of endometrial carcinoma

作　　者：赵昕[1] 马淑芬[1] 

机构地区：[1]河北医科大学第二医院妇产科,石家庄市050000

出　　处：《河北医药》2009年第17期2213-2214,共2页Hebei Medical Journal

基　　金：河北省医学科学研究重点课题计划项目(编号:08094)

摘　　要：目的探讨转化生长因子β1(TGF-β1)及其Ⅱ型受体(TGFβR-Ⅱ)与子宫内膜癌发生的关系。方法采用免疫组织化学方法检测子宫内膜癌、子宫内膜复杂增生、正常子宫内膜组织中TGF-β1及TGFβR-Ⅱ的表达。利用CD34相关抗原标记血管内皮细胞,计数微血管密度(MVD)。结果子宫内膜癌及复杂增生组织中TGF-β1表达明显高于正常子宫内膜组织(P<0.05或P<0.01),而前两者之间差异无统计学意义(P>0.05)。从正常子宫内膜、复杂增生到子宫内膜癌组织中TGFβR-Ⅱ表达逐渐下降甚至缺如,且两两差异均有统计学意义(P<0.05)。子宫内膜癌组织中MVD高于复合增生组及正常子宫内膜(P<0.05),与TGF-β1呈正相关(r=0.182,P<0.01)。结论TGF-β1过度表达促进子宫内膜癌的生长与血管发生,可能是子宫内膜癌发生的早期现象,其负性调控的丧失与TGFβR-Ⅱ表达下降或缺如有关。Objective To investigate the correlation between the expression of transforming growth factor β1 （TGF-β1） as well as its receptor （TGFβR-Ⅱ ）and the genesis of endometrial carcinoma. Methods The expression of TGF-β1 and TGFβR-Ⅱ in the tissues of endometrial carcinoma, complex hyperplasia and normal endometrium tissues were detected by immunohistochemistry. The microvessel density （MVD） was highlighted by immunohistochemical staining to detect CD34 antigen. Results The exepression of TGF-β1 in endometrial carcinoma and complex hyperplasia was significantly increased, as compared with that in normal endometrium tissues （ P 〈0.05 or 〈0. 01 ） ,but there was no significant difference between endometfial carcinoma and complex hyperplasia （ P 〉 0. 05 ）. The expression of TGFβR- Ⅱ was gradually decreased in the order of normal endometrium tissues, complex hyperplasia, endometrial carcinoma, and there were significant differences among them （ P 〈 0.05 ）. The MVD in the tissues of endometrial carcinoma was significantly higher than that in the tissues of complex hyperplasia and normal endometrium （ P 〈0.05 ） ,which was positively correlated with TGF-β1 （ r =0. 482, P 〈 0.01 ）. Conclusion The overexpression of TGF-β1 may result in the development and angiogenesis of endometrial carcinoma,which may be the early phenomenon of endometrial carcinoma. The loss of negative regulation of TGF-β1 is correlated with the decrease or loss of TGFβR-Ⅱ expression.

关 键 词：转化生长因子Β 微血管密度 子宫内膜肿瘤 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]