β-胡萝卜素口服液的稳定性研究  

Studies on stability of β-carotene oral liquid

作　　者：于小华[1] 刘晓华[1] 李纯球[1] 赵浩如[1] 

机构地区：[1]中国药科大学中药制剂教研室,南京210038

出　　处：《海峡药学》2009年第8期23-25,共3页Strait Pharmaceutical Journal

摘　　要：目的考察β-胡萝卜素口服液的稳定性影响因素及增加稳定性的方法。方法采用单因素分析法考察光线、空气(O2)、温度、金属离子、pH值等的影响及筛选增加稳定性的方案。结果各因素的影响程度:温度>光照>O2>金属离子>pH值;加入0.05%的维生素E可增加本品的稳定性。结论本品不稳定,在生产和储存过程中要低温、避光、避氧及加入抗氧剂。OBJECTIVE To investigate the factors which influence the stability of β-Carotene oral liquid and how to increase the stability. METHODS The single-factor analysis was used to study the effects of light, O2, temperature、metalion, pH value and screen the methods to increase the stability. RESULTS The effect degree of various factors： temperature 〉 light 〉 O2 〉 metalion 〉 pH value; add 0.05 % of vitaminE can increase the stability of β-Carotene oral liquid. CONCLUSION β-Carotene oral liquid is unstable, which should be under low temperature, avoid light and O2, add oxidation-resistant during the process of production and storage.

关 键 词：Β-胡萝卜素 稳定性 口服液 

分 类 号：R977.21[医药卫生—药品] R286.0[医药卫生—药学]