乳腺癌巨噬细胞移动抑制因子、人表皮生长因子受体-2和p53的表达与临床意义  

MIF,CerBb-2 and p53 expressions in breast cancer., correlation with clinicopathological features

作　　者：张春丽[1] 杨敏[1] 

机构地区：[1]浙江省立同德医院病理科,杭州310012

出　　处：《浙江医学》2009年第1期18-21,共4页Zhejiang Medical Journal

摘　　要：目的研究巨噬细胞移动抑制因子（MIF）、人表皮生长因子受体-2（CerBb-2）和p53在乳腺浸润性导管癌中的表达，以及与临床病理特征的关系。方法对37例乳腺浸润性导管癌手术标本和20例癌旁组织标本进行MIF、CerBb-2和p53免疫组化检测，观察MIF、CerBb-2和p53在乳腺浸润性导管癌组织和癌旁组织中表达的差异，分析其与乳腺浸润性导管癌临床病理特征之间的关系。结果MIF、CerBb-2和p53在乳腺浸润性导管癌组织和癌旁组织中的表达阳性率分别为70．3％和25．0％、393％和100％、43.2％和150％，3项指标在癌组织和癌旁组织中表达的差异均有统计学意义（均P〈0．05）。MIF、p53均与组织学分级、淋巴结转移有密切关系（均P〈0.05），与其它病理特征无关（P〉0.05）；CerBb-2与组织学分级、淋巴结转移及TNM分期有密切关系（均P〈0.05），其低表达与ER、PR高表达有密切关系（P〈0.05），与其它病理特征无关（P〉0.05）；MIF、CerBb-2与p53共同表达与组织学分级、淋巴结转移及TNM分期密切相关（P〈0.05）；CerBb-2与p53呈正相关（P〈0.05）。结论MIF、CerBb-2和p53的表达与乳腺癌发生、发展及侵袭转移有关，三者同时高表达提示肿瘤具有更高的侵袭转移能力。Objective To investigate the expressions of MIF, CerBb-2 and p53 in human breast carcinoma and their correlations with clinicopathological features. Methods By using immunohistochemical methods, the expressions of MIF, CerBb-2 and p53 were detected in 37 infiltrating ductal breast carcinoma and 20 surrounding normal mammary gland tissues, and the correlations with clinicopathological features were analyzed. Results The positive expression rates of MIF, CerBb-2 and p53 were 70.3%, 39.3% and 43.2% in the infiltrating ductal breast carcinoma, meanwhile those were 25%, 10% and 15% in surrounding normal mammary gland tissues （P〈0.01）. The expressions of MIF and p53 were positively correlated with histological grade and lymph node metastasis （P〈0.05）. The expression of CerBb-2 was positively correlated with histological grade, lymph node metastasis and clinical stages （P〈0.05）, but negatively correlated with ER and PR expression （P〈0.05）. The co-expression of these three proteins was positively correlated with histological grade, lymph node metastasis and clinical stages （P〈0.05）. And the expressions of CerBb-2 and p53 were positive correlated in the breast cancer. Conclusion The expressions of MIF, CerBb-2 and p53 might be associated with carcinogenesis and development of breast carcinoma, which can be used as the indicators for aggression and metastasis of the cancer.

关 键 词：乳腺癌 MIF CERBB-2 P53 

分 类 号：R737.9[医药卫生—肿瘤] R563.8[医药卫生—临床医学]