CK5／6和AR在三阴性乳腺癌中的表达及其与临床病理特征的联系  

The expression of CK5J6 and AR in ＂triple-negative＂ breast cancer and their relationship with clinicopathological parameters

作　　者：李中琦[1] 郑怡[1] 滕晓东[2] 严丽萍[2] 滕理送[1] 

机构地区：[1]浙江大学医学院附属第一医院肿瘤外科,杭州310003 [2]浙江大学医学院附属第一医院病理科,杭州310003

出　　处：《浙江医学》2009年第1期49-51,共3页Zhejiang Medical Journal

摘　　要：目的探讨细胞角蛋白5／6（CK5／6）和雄激素受体（AR）在三阴性乳腺癌和非三阴性乳腺癌组织中的表达特点及其与相应临床病理特征的关系。方法应用免疫组化法检测75例三阴性乳腺癌和84例非三阴性乳腺癌中CK5／6和AR的阳性表达率，并对相应病例的临床病理资料进行统计分析。结果三阴性乳腺癌CK5／6的阳性表达率86.7％，明显高于非三阴性乳腺癌48％（X^2=108．2，P〈0．01）；AR的阳性表达率253％，明显低于非三阴性乳腺癌82．1％（X^2=51．74，P〈001）；CK5／6在三阴性乳腺癌中的表达与患者年龄、月经状态、肿瘤分期、肿瘤大小和淋巴结累及情况均无关（均P〉0．05），而AR在三阴性乳腺癌中的表达与肿瘤分期有关（P〈005），与患者年龄、月经状态、肿瘤大小和淋巴结累及情况均无关（均P〉0．05）。结论CK5／6的高表达和AR的低表达在三阴性乳腺癌中具有明显特征，CK5／6不随肿瘤临床病理指标变化而具有稳定的高表达率，反映了三阴性乳腺癌的基底样表型特征，而AR的阳性表达率随肿瘤分期的升高而降低则可能与肿瘤的侵袭进展有关。Objective To investigate the expression of CK5/6, AR and their relationship with clinicopathological parameters in ＂triple-negative＂ （negative estrogen receptor, negative progesterone receptor and negative Her-2）and ＂non-triple negative＂ breast cancers. Methods Immunohistochemical assays were performed to determine the expression of CK5/6 and androgen receptor （AR） in 75 cases of triple-negative breast cancer and 84 cases of non-triple negative breast cancer. Meanwhile, the relationships between immunohistochemical results and clinicopathological data were analyzed. Results The expression of CK5/6 was more frequently detected in triple negative breast cancer （86.7% vs 4.8%, P〈0.01） and was not correlated with age, menopausal status, lymphadenopathy, tumor size and stage （P〉0.05）, while AR was more likely to express in non-triple negative breast cancer （82.1% vs 25.3%, P〈0.01） and was correlated with tumor stage （P〈0.05）. Conclusion High expression level of CK5/6 and low expression level of AR are characteristics of triple-negative breast cancer, which reflects its basal-like phenotype.

关 键 词：三阴性乳腺癌 CK5/6 AR 免疫组化法 

分 类 号：R737.9[医药卫生—肿瘤] R735.2[医药卫生—临床医学]