New cytotoxic cerebroside from Gynura divaricata  

作　　者：Lei Chen Jin Jiang Wang Hong Tao Song Guo Gang Zhang Lu Ping Qin 

机构地区：[1]Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China [2]Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China [3]School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

出　　处：《Chinese Chemical Letters》2009年第9期1091-1093,共3页中国化学快报（英文版）

基　　金：supported by the Scientific Research Fund of Fujian Provincial Department of Science &Technology(No.2008Y0086);the Traditional Chinese Medicine Research Fund of Fujian Provincial Public Health Bureau(No.wzy0606),China

摘　　要：A new cerebroside, gynuraoside （1）, was isolated from the aerial parts of Gynura divaricata DC. It was determined to be 1-0-13- o-glucopyranosyl-（2S,3 S,4R, 10E）-2- [（2＇R）-2^-hydroxyldocosanoyl-amino]- 10-octadecene- 1,3,4-triol on the basis of chemical and spectroscopic evidence. This compound showed strong cytotoxicity against L1210 leukemia cell line in vitro. 2009 Hong Tao Song. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.A new cerebroside, gynuraoside （1）, was isolated from the aerial parts of Gynura divaricata DC. It was determined to be 1-0-13- o-glucopyranosyl-（2S,3 S,4R, 10E）-2- [（2＇R）-2^-hydroxyldocosanoyl-amino]- 10-octadecene- 1,3,4-triol on the basis of chemical and spectroscopic evidence. This compound showed strong cytotoxicity against L1210 leukemia cell line in vitro. 2009 Hong Tao Song. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关 键 词：Gynura divaricata CEREBROSIDE CYTOTOXICITY 

分 类 号：Q959.133[生物学—动物学] S644.904.7[农业科学—蔬菜学]