cFLIP与黑素瘤研究进展  

Cellular FLIP and melanoma

作　　者：陆捷洁[1] 杨井[1] 陶娟[1] 涂亚庭[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤科,武汉430022

出　　处：《国际皮肤性病学杂志》2009年第5期327-329,共3页International Journal of Dermatology and Venereology

摘　　要：cFLIP是近年来发现的一种凋亡抑制蛋白，通过抑制caspase-8的活化阻断死亡受体介导的凋亡信号。cFLIP还参与多种信号通路的传递。最近研究发现，cFLIPL还可以活化caspase-8。cFLIP的高表达与许多肿瘤相关，在黑素瘤组织及多种黑素瘤细胞系中存在cFLIP的高表达，向黑素瘤细胞引入cFLIP小干扰RNA，通过化疗药物或者UVB联合TRAIL阻断cFLIP的功能，能促进黑素瘤细胞的凋亡。Cellular FLIP （cFLIP） is a newly discovered anti-apoptotic protein that could block death receptor signaling pathways via modulating the activation of caspase-8. Recent studies have shown that cFLIP could activate caspase-8. The high expression of caspase-8 is associated with many tumors. For example, there is a high expression of caspase-8 in melanoma tissue and melanoma cell lines; to block the function of cFLIP by introducing cFLIP-targeting small interfering RNA into melanoma cell lines, chemotherapy, or ultraviolet B plus tumor necrosis factor related apoptosis-inducing ligand （TRAIL） would accelerate the apoptosis of melanoma cells.

关 键 词：黑色素瘤 CASP8和FADD样细胞凋亡调节蛋白质 受体 TNF相关凋亡诱导配体 

分 类 号：R739.5[医药卫生—肿瘤]