增强NK细胞肿瘤杀伤活性的研究进展  被引量:11

Advances of enhancing cytotoxicitiy of NK cells

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作  者:赵敬湘[1] 王字玲[1] 

机构地区:[1]军事医学科学院野战输血研究所,北京100850

出  处:《中华肿瘤防治杂志》2009年第16期1267-1271,共5页Chinese Journal of Cancer Prevention and Treatment

摘  要:目的:综述分析国内外增强自然杀伤细胞(naturalkillercell,NK)对肿瘤杀伤活性的研究现状,为基础与临床研究提供研究方向、思路和资料。方法:应用PubMed和万方数据库等检索系统,以NK细胞、肿瘤和细胞毒等为关键词,检索1998-01-2008-07与NK细胞肿瘤杀伤相关的文献。纳入标准:NK细胞在肿瘤免疫治疗中的基础与临床研究。粗选230篇文献,最后34篇纳入综述分析。结果:NK细胞是一种独特的淋巴细胞,对靶细胞的识别无MHC限制性,无需预先致敏即可直接杀伤肿瘤细胞,也可分泌细胞因子调节其他免疫细胞的功能,是机体天然免疫的主要承担者,也是获得性免疫的核心调节细胞,故NK细胞在抗肿瘤免疫中的地位越来越受到重视,随之增强NK细胞肿瘤杀伤活性的研究也逐步深入。可以通过细胞因子、单抗及多功能抗体介导NK细胞活化,通过调节抑制性信号和活化性信号传递加强NK细胞活性,通过免疫药物刺激及基因修饰提高NK细胞功能等多种途径增强NK细胞的肿瘤杀伤作用。结论:研究增强NK细胞杀伤活性的方法,将促进NK细胞在肿瘤免疫治疗中的应用。OBJECTIVE: To discuss the strategies used to enhance the NK cell cytotoxicity to tumors. METHODS: Papers on NK cytotoxicity and cancer immunotherapy treatment, published from Jan. 1998 to July. 2008, were retrieved in PubMed and Wanfang database by using the key words "natural killer cell, cytotoxicity and tumor". Criteria of paper adoption: The immunotherapy of NK cell to tumors in faundation and clinical research. After that, 230 papers were selected, and 34 papers out of them were finally analyzed and reviewed. RESULTS: NK cells represent a unique subset of lymphocytes that have no restriction by MHC antigens and have the ability to lyses certain tumor cells without the requirement for prior immune sensitization of the host. In addition, NK cells can also produce eytokines and regulate the function of other immune cells. So, it is emerging to apply NK cells as therapeutic agents against a broad range of malignancies. In this respect, the anti-tumor activity of NK cells is the key factor of NK-cell-based immunotherapy. Several strategies such as harnessing NK cells through cytokines and bispecific antibodies, manipulating inhibitory versus activating receptors of NK cells, and genetically modified NK cells, can be used to enhance NK-cell responses to tumors. CONCLUSION:The development of new methods to improve NK cell activity is needed to strengthen ability to harness the power of NK cells for cancer treatment aims.

关 键 词:肿瘤 自然杀伤细胞 活性 策略 综述文献 

分 类 号:R730.5[医药卫生—肿瘤]

 

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