血管紧张素Ⅱ的Ⅰ型受体与原发性高血压的相关性研究  

ASSOCIATION BETWEEN ANGIOTENSIN Ⅱ TYPE Ⅰ RECEPTOR GENE AND HUMAN ESSENTIAL HYPERTENSION

作　　者：樊红[1,2] 李少英[1,2] 顾维娟 李月秋[1,2] 马洪星[1,2] 罗佳滨[1,2] 王文臣[1,2] 吕学冼 

机构地区：[1]佳木斯医学院生物教研室 [2]佳木斯市中心医院神经内科

出　　处：《中华医学遗传学杂志》1998年第2期101-103,共3页Chinese Journal of Medical Genetics

摘　　要：目的确定血管紧张素Ⅱ的Ⅰ型受体与原发性高血压的关系，探索原发性高血压的发病机理。方法应用聚合酶链式反应、限制性内切酶酶解、电泳分型的方法，在中国人群中分析了血管紧张素Ⅱ的Ⅰ型受体基因中Ａ１１６６→Ｃ位点的多态性分布。结果５１例原发性高血压中Ａ１１６６→Ｃ突变体频率为０．０９８，而在７４例正常人群组中的该位点突变体频率为０．０４１，经统计学分析两组间有显著差异（Ｐ＜０．０５）。即高血压组该突变体频率明显高于正常对照组。Objective To determine whether the angiotensin Ⅱ type Ⅰ receptor gene might be implicated in human essential hypertension.Methods This was a case control study on hypertension and normal blood pressure in Chinese DNA abstracted samples from 51 cases of essential hypertension and 74 normal controls were analysed by polymerase chain reaction, digestion of restriction enzyme and electrophesis.Results The genotype frequency of 1166A/1166C was 0.196(10/51) in the essential hypertension group, 0.081(6/74) in the control group. The genotype frequency of 1166C/1166C was 0.000 in both groups. The gene frequency of 1166C was 0.098 in the essential hypertension group, 0.041 in the controls. There was a significant increase in allelic frequency of 1166C in hypertension.Conclusion The results indicate that the increase in allelic frequency of 1166C is a risk factor and hence suggest that the change in the angiotensin Ⅱ type Ⅰ receptor gene is associated with essential hypertension.

关 键 词：原发性高血压 血管紧张素Ⅱ的Ⅰ型受体 多态性 

分 类 号：R544.102[医药卫生—心血管疾病]