Alzheimer型痴呆的CT与MRI研究  

The Role of CT and MRI in the assessment of dementia of Alzheimer type

作　　者：赵虹[1,2] 王峻[1,2] 李彬祥 白培琛 马锦堂[1,2] 

机构地区：[1]山西医科大学第一临床医院CT室 [2]山西医科大学第二临床学院MRI室

出　　处：《中华放射学杂志》1998年第4期235-238,共4页Chinese Journal of Radiology

摘　　要：目的验证海马萎缩在Ａｌｚｈｅｉｍｅｒ型痴呆（ＤＡＴ）中作为一种预测标志的价值，为临床提供辅助诊断方法。材料与方法选３０名受检者全部通过简易精神状态检查（ｍｉｎｉ－ｍｅｎｔａｌｓｔａｔｅｅｘ－ａｍｉｎａｔｉｏｎ，ＭＭＳＥ），ＣＴ扫描观察海马周围裂的变化，并测量海马内侧的脑脊液池（ＨＣＳＦ），即测量环池内侧边到颞叶内侧边之间的距离。选其中１３名行ＭＲＩ扫描测量海马结构（ＨＦ）体积。结果在正常人中区分Ａｌｚｈｅｉｍｅｒ型痴呆病人最敏感的测量是ＭＭＳＥ，最特异性的测量是ＨＣＳＦ。ＨＦ体积与ＭＭＳＥ在正常组中无相关性，而在ＤＡＴ组中有显著的相关关系。Purpose To test the predictive value of atrophy of hippocampal formation(HF) in detecting dementia of Alzheimer type(DAT) patients with CT and MRI. Materials and methods A total of 30 subjects (13 DAT patients and 17 normal volunteers)were studied with CT. The MR examinations were performed in 13 subjects(8 DAT and 5 normal). The width of choroidal fissure/hippocampal fissure on CT and MR imaging was measured to assess the HF volume. Results MMSE sensitivity exceeded that of choroidal fissure/hippocampal fissure in DAT patients and the specificity of choroidal fissure/hippocampal fissure was superior to that of MMSE in normal volunteers. A significant correlation ( P <0.05)between MMSE score and HF volume was observed in all DAT patients. Conclusion Dilatation of choroidal fissure/ hippocampal fissure and reduction of HF volume were a useful radiologic marker for the diagnosis of DAT.

关 键 词：早老性痴呆 痴呆 CT 诊断 磁共振成像 

分 类 号：R749.160.4[医药卫生—神经病学与精神病学]