抗病毒口服液中单味中药定性定量方法的研究  

Study on the qualitative and quantitative methods of single herb in Anti-virus Oral Liquid

作　　者：邓丽明[1] 陈航[2] 

机构地区：[1]东南大学附属中大医院药剂科,江苏南京210009 [2]江苏省食品药品检验所,江苏南京210008

出　　处：《南京医科大学学报（自然科学版）》2009年第9期1251-1256,共6页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:研究抗病毒口服液中单味中药定性定量方法,提高抗病毒口服液的质量控制标准。方法:在定性研究方面,采用薄层层析法对连翘、知母、石菖蒲进行鉴别,并探讨了广藿香和地黄等药材的薄层鉴别方法;在含量研究方面,建立了HPLC法测定抗病毒口服液中连翘苷含量的方法。结果:知母、石菖蒲和连翘的薄层色谱鉴别专属性强,阴性对照无干扰。翘苷平均回收率为99.42%,RSD=1.75%。结论:本法简便、准确,专属性强,可对该药品进行有效的质量控制。Objective：To study the qualitative and quantitative methods of single herb in Anti-virus Oral Liquid,and improve the quality standard of Anti-virus Oral Liquid. Methods： On qualitative study,Fructus Forsythiae ,Rhizoma anemarrhenaeand and Rhizorna A cori Tatarinowii were identified by thin-layer chromatography（ TLC ）,and Herba Pogostemonis ,Radix Rehmanniae were also studied. On quantitative study,the method of high performance liquid chromatography （HPLC） for determination of phillyrin in Anti-virus Oral Liquid was established. Results：Rhizoma anemarrhenae ,Rhizoma A cori Tatarinowii and Fructus Forsythiae can be identified by TLC. The average recovery of Phillyrin was 99.42% ,RSD =1.75%. Conclusion：The method is simple,accurate and specific,and can be used for the quality control of Anti-virus Oral Liquid.

关 键 词：抗病毒口服液 质量标准 薄层色谱法 高效液相色谱法 含量测定 

分 类 号：R282.5[医药卫生—中药学]