Infliximab治疗难治性克罗恩病并发腹腔脓肿1例  

Intra-abdominal abscess develops during infliximab treatment of refractory Crohn's disease:a report of one case

作　　者：庞智[1] 沈必武[1] 郑家驹[1] 

机构地区：[1]江苏省苏州市立医院北区消化内科,江苏省苏州市215008

出　　处：《世界华人消化杂志》2009年第21期2221-2222,共2页World Chinese Journal of Digestology

摘　　要：患者1例:反复腹痛、腹泻12年余,加重20d伴发热入院,据临床表现、影像学及肠镜检查确诊为难治性克罗恩病,于0,2,6wk时,静脉滴注Infliximab(5mg/kg)进行诱导治疗,隔8wk后再予静脉滴注1次,进行维持缓解治疗.患者于首次滴注后21wk发生腹腔脓肿.提示接受Infliximab治疗的患者可能增加感染的潜在危险,值得引起重视.A male patient who had recurrent abdominal pain and diarrhea for more than 12 years was admitted to our hospital because of symptom exacerbation and fever for 20 days.According to clinical,imaging and colonoscopic manifestations,he was diagnosed as rfractory Crohn’s disease.He was treated intravenously with infliximab at a dose of 5 mg/kg at weeks 0,2,and 6 for induction therapy,followed by an 8-week interval maintenance treatment.Intra-abdominal abscess developed at week 21 after the first infliximab infusion,suggesting that infliximab treatment of refractory-Crohn＇s disease may increase the risk of infection.

关 键 词：INFLIXIMAB 难治性克罗恩病 腹腔脓肿 

分 类 号：R574[医药卫生—消化系统] R656[医药卫生—内科学]