FGFR2和c-Cbl在胃癌组织中的表达及其临床意义  

The expression and clinical signifi cance of FGFR2, and c-Cbl in gastric carcinoma

作　　者：李琳琳[1,2] 刘云鹏[1] 侯柯佐[1] 曲秀娟[1] 李强[2] 董茜[1] 宋娜[1] 

机构地区：[1]中国医科大学附属第一医院肿瘤内三科,辽宁沈阳110001 [2]辽宁省肿瘤医院肿瘤内科,辽宁沈阳110042

出　　处：《中国癌症杂志》2009年第8期609-614,共6页China Oncology

摘　　要：背景与目的:FGFR2是受体型酪氨酸激酶,c-Cbl是泛素-蛋白酶体通路中的一个新的RING Finger型泛素连接酶,本研究探讨FGFR2和c-Cbl在胃癌组织中的表达及其临床意义。方法:构建胃癌组织芯片,应用免疫组化SP法,检测两种蛋白的表达情况。结果:FGFR2和c-Cbl在胃癌组织中的阳性表达率分别为77.4%和71.0%。FGFR2蛋白表达与浸润深度及病理分期有关(P<0.05),而与性别、年龄、分化程度及淋巴结转移无关;c-Cbl蛋白表达与浸润深度及病理分期有关(P<0.05),而与性别、年龄、分化程度及淋巴结转移无关。FGFR2与c-Cbl的表达强度呈正相关。结论:FGFR2和c-Cbl在胃癌中高表达;FGFR2及c-Cbl蛋白的表达强度与胃癌的浸润深度及病理分期均呈正相关;FGFR2与c-Cbl的表达强度均呈正相关。Background and purpose： FGFR2 is a receptor tyrosine kinase and c-Cb1 is a new RING finger type of ubiquitin ligase in the ubiquitin-proteasomes path. The purpose of this study was to evaluate the expression and significance of FGFR2 and c-Cb1 in gastric carcinoma. Methods： The expression of FGFR2 and c-Cb1 were detected by immunohistochemical method of SP. Results： The positive expression rates of FGFP,2 and c-Cb1 were 77.4%,71.0% in gastric carcinoma, respectively, both were higher than those normal tissue （P〈0.05）; The expression of FGFR2 and c-Cb1 were positively correlated with depth of invasion and TNM staging, and there was a positive relationship between the expressions of FGFR2 and c-Cb1. Conclusion： The expressions of FGFR2 and c-Cb1 were associated with some clinicopathologic features in gastric carcinoma, indicating that their expression may be the prognostic factors for gastric carcinoma.

关 键 词：胃癌 组织芯片 FGFR2 C-Cb1 

分 类 号：R735.2[医药卫生—肿瘤] R730.2[医药卫生—临床医学]