奥氮平辅助治疗难治性抑郁症患者的疗效及对生活质量的影响  

Efficacy and effect on quality of life of Olanzapine as an Augmentation in treating patients with Refractory Depression

作　　者：余学[1] 赵福涛[1] 刘向阳[1] 孙群星[1] 

机构地区：[1]河南省驻马店市精神病医院,463000

出　　处：《中国实用医药》2009年第25期18-19,共2页China Practical Medicine

摘　　要：目的探讨奥氮平辅助治疗难治性抑郁症患者的疗效及对生活质量的影响。方法68例难治性抑郁症患者随机分为研究组(奥氮平+舍曲林n=34)和对照组(单用舍曲林n=34),疗程8周。以汉密尔顿抑郁量表(HAMD)及不良反应量表(TESS)分别在治疗前及治疗第1、2、4、6和8周末各评定1次,以生活质量综合问卷(GQOLI-74)在治疗前和治疗后8周末各评定一次生活质量。结果研究组于第1周末起效,对照组于第2周末起效,治疗后1、2、4、6周末HAMD评分差异有统计学意义(P<0.01)。两组间TESS评分差异无统计学意义(P>0.05)。8周末,研究组除物质生活维度外,其他维度得分明显高于对照组,有显著性差异(P<0.01)。结论奥氮平辅助治疗难治性抑郁症起效快,可增加疗效,优于单用舍曲林治疗,且明显改善患者的生活质量。Objective To study the efficacy and effect on quality of life of Olanzapine as an Augmentation in treating patients with Refractory Depression. Method 68 patients with refratory depression were randomly assigned to research group （ sertraline combined with olanzapine, n = 34） and control group （ single sertraline, n = 34） for 8 weeks. Hamilton Depression rating scale （HAMD） , Treatment Emergent symtom scale TESS） were used to assess the efficacy and side effects respectively before treatment and after treatment 1,2,4, 6,8 weekends. General quality of life inventory （GQOLI） was analyzed at baseline and the end of the study. Results The therapeutic efficacy in research group was observed at 1 weedend, while in control group at 2 weekend. The scores of HAMD in study group were significant lower than those in control group at 1,2,4,6 weekend（ P 〈 0. 01 ）. There was no significant difference of score of TESS between the two groups （ P 〉 0. 05）. After 8 weeks treatment , the research group improved obviously the quality of life except the materiai life factor. Conclusion It is suggested that Olanzapine-assisted treatment of refractory depression, fast onset, may increase the curative effect, be superior to sertraline alone treatment, and improve the patients＇ s quality of life obviously.

关 键 词：奥氮平 难治性抑郁症 舍曲林 生活质量 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]