睑板腺分泌异常与干眼症的临床研究  

Abnormal Property of Meibomian Secretion and Dry Eye Syndrome

作　　者：刘历东[1] 艾育德[1] 

机构地区：[1]内蒙古医学院附属医院眼科,内蒙古呼和浩特010050

出　　处：《内蒙古医学杂志》2009年第7期772-774,共3页Inner Mongolia Medical Journal

摘　　要：目的:探讨异常睑板腺分泌物和干眼症的关系。方法:在门诊连续观察52例共104眼。常规检查裸眼视力、矫正视力,并行眼球前段及眼底检查。进行泪膜破裂时间(BUT)、Schirmer Ⅰ试验,观察记录睑板腺分泌物的性质。按病情轻重将干眼症分为轻度和重度。结果:透明蛋清样分泌物20眼,奶黄样分泌物20眼,颗粒状分泌物22眼,牙膏状分泌物42眼。本组共有46眼(44%)符合干眼症诊断标准,各组患干眼症的构成比依次升高,透明样(2/20)10%、奶黄样(4/20)20%、颗粒状(6/22)27%、牙膏状(34/42)81%。牙膏状分泌物组的BUT和荧光素钠积分明显高于其他3组(两两比较,P均<0.01)。各组SchirmerⅠ积分均在1分以下,组间比较差异无统计学意义。透明样和奶黄样分泌物组无重度干眼症患者,6眼颗粒状分泌物中重度干眼症占2眼,而34眼牙膏状分泌物中16眼发生重度干眼症。牙膏状分泌物发生重度干眼症高于非牙膏状类型分泌物(P<0.05)。结论:异常睑板腺分泌物影响眼表面的稳定性,其中牙膏状分泌物患者干眼症程度较其它分泌物组重。Objective：To study the relationship between meibomian secretion and dry eye.Methods：To observe 52 outpatients（104 eyes）consecutively.Routine check upincluded vision,anterior segment and fundus,scoring of tear break up time（BUT）,Schirmer Ⅰ test and fluorescein staining.Recorded the property of meibomian secretion.Defined the dry eye as mild and severe.Results：Meibomian secretion was sorted as egg-white-1ike secretion（n=20）,milk yellowish secretion（n=20）,granular secretion（n=22）and toothpaste-like secretion （n = 42）. 46 eyes（44 % ）met the criteria of dry eye syndrome. The incidence of dry eye stepped up in groups as egg - white - like secretion （ 2/20 ） 10 %、 milk - yellowish secretion （4/20） 20 % 、 granular secretion （ 6/22 ） 27 % and toothpastelike secretion（34/42）81%. The result declared that BUT and fluorescein scoring was higher in toothpaste - like secretion than in other groups（all P 〈 0.01）. Schirmer Ⅰscoring was below 1 in all groups, and there was no difference in the groups. The incidence was higher in granular secretion than in egg - white - like secretion（P 〈 0.05）, while the incidence was higher in toothpastelike secretion than in any of other 3 groups （P 〈 0.01 ）. There was no severe dry eye in egg - white - like secretion and milk - yellowish secretion, while dry eye was found in 2 out of 6 in granular secretion, and in 16 out of 34 in toothpaste - like secretion. Incidence of severe dry eye was found higher in toothpastelike secretion than in non toothpastelike secretion （P 〈 0.05）. Conclusion： Abnormal meibomian secretion affects the stability of ocular surface. The patients with toothpaste - like secretion are prone to dry eye and tend to have a worse dry eye than other secretion groups.

关 键 词：睑板腺 分泌物 干眼症 

分 类 号：R777.1[医药卫生—眼科] R77[医药卫生—临床医学]