血清NSE和S-100β蛋白在癫痫急性发作患者中的变化及临床价值  

The Changes of the Levels of Serum NSE and S-100β Protein in Patients with Seizure of Epilepsy and Its Clinical Significance

作　　者：陈萍[1] 李自如[1] 马翔凌[1] 

机构地区：[1]内蒙古自治区医院神经内科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2009年第7期788-789,共2页Inner Mongolia Medical Journal

摘　　要：目的:观察血清神经元特异性烯醇化酶(neuron specific enolase,NSE)和S-100β蛋白在癫痫(Epilepsy,EP)急性发作患者中的变化,从而估测癫痫(Epilepsy,EP)急性发作后脑损伤程度。方法:用化学发光免疫法测定癫痫急性发作患者24h内和正常对照组血液NSE和S-100β蛋白含量并进行统计学处理。结果:癫痫急性发作患者的血清NSE和S-100β蛋白浓度明显高于对照组(P<0.01)。结论:癫痫急性发作患者的血清NSE和S-100β蛋白明显增高,其增高程度与癫痫发作后脑损伤程度有关。Objective：To observe the changes of the levels of serum NSE and S-100β protein in patients with seizure of epilepsy ,for evaluating the severity of brain injuries after seizure of epilepsy. Methods：The levels of serum NSE and S-100β protein in patients with epilepsy within 24 hours of seizure and controls were detected by chemiluminescence immunoassay ,then were statistically analyzed. Results： The levels of serum NSE and S-100 β protein in patients with seize of epilepsy were higher than those in controls（P〈0.01）.Conclusion： The levels of serum NSE and S-100β protein in patients with seize of epilepsy increases with the severity of brain injuries.

关 键 词：癫痫 神经元特异性烯醇化酶 S-100Β蛋白 

分 类 号：R742.1[医药卫生—神经病学与精神病学]