胃癌患者血脂水平与肿瘤组织分化程度的相关性研究  

Correlation among differentiation, serum cholesterol, LDL and HDL in patients with gastric cancer

作　　者：陈瑞云[1] 郭震[2] 王春祥[3] 王培林[1] 于文滨[1] 

机构地区：[1]山东大学第二医院普外科,山东济南250033 [2]聊城市人民医院胃肠外科,山东聊城252000 [3]济南市第三人民医院普外科,山东济南250101

出　　处：《中国现代普通外科进展》2009年第8期683-685,701,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:测定胃癌患者血清总胆固醇(TC)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)的含量,探讨三者与胃癌不同分化程度之间的相关性。方法:143例胃癌患者根据组织病理类型分为:1)高分化组,包括乳头状腺癌16例和管状高分化腺癌43例;2)中分化组,包括管状中分化腺癌39例;3)低分化组,包括低分化腺癌20例、黏液腺癌14例和印戒细胞癌11例。胃溃疡患者和体格检查正常者各30例作为对照。所有被选中者取空腹静脉血,酶法测定血清TC水平,沉淀法测定血清LDL和HDL水平。结果:胃癌患者的检测值较正常对照组和胃溃疡组明显降低(P<0.05),正常对照组和胃溃疡组之间差异无统计学意义(P>0.05),胃癌各分化组的患者血清TC、LDL和HDL差异有统计学意义(P<0.05)。随访40例胃癌患者术后血清TC、LDL和HDL水平明显高于术前(P<0.05)。结论:胃癌患者血清TC、LDL和HDL水平与胃癌组织分化程度相关,癌组织分化越差,血清TC、LDL和HDL水平越低。Objective： To survey the content of serum total cholesterol, LDL and HDL in patients with gastric cancer and to investigate the correlation between serum total cholesterol, LDL, HDL and the differentiation of gastric cancer. Methods： 143 patients with gastric cancer were selected and assigned into 3 groups according to pathology grouping after operation： 1） the well-differentiated group, consisting of 16 patients with papillary adenocarcinoma, and 43 patients with tubiform well-differentiated adenocarcinoma; 2） the moderately differentiated group, including 39 patients with tubiform moderately differentiated adenocarcinoma, 3） the poorly differentiated group, including 20 patients with poorly differentiated adenocarcinoma, and 14 patients with mucinous adenocarcinoma, and 11 patients with signet-ring cell carcinoma. In addition, 30 patients with gastric ulcer and 30 health adults were selected as control. Veinous blood of every member was collected, and then the content of serum total cholesterol was surveyed by enzymic method, and the contents of serum LDL and HDL were measured by precipitation method. Results： The level of serum total cholesterol, LDL and HDL before operation in patients with gastric cancer decreased significantly than those with gastric ulcer and normal people （P〈0.05）, but there was no statistically significance between two controls（P〉0.05）. There was statistically significance among different differentiation in patients with gastric cancer. The differences of levels of serum total cholesterol, LDL and HDL were statistically significant in gastric cancer of different differentiated groups. The contents of serum cholesterol, LDL and HDL in 40 patients with gastric cancer after operation were higher than those before operation obviously （P〈0.05）. Conclusion： There is a correlation between the level of serum total cholesterol, LDL, HDL and the tissues differentiation of gastric cancer, The lower the tissues differentiation, the lower the level of serum total cho

关 键 词：胃肿瘤 胆固醇 

分 类 号：R735.2[医药卫生—肿瘤]