武汉地区目标人群结直肠癌筛查4年初步报告  

Preliminary report about the screening program for colorectal cancer by sequential fecal occult blood in Wuhan area for 4 years

作　　者：路直美 陈继贵 张宇星 王倩 徐俊 陈超 杨睿 熊非 刘畅 彭献华 

机构地区：[1]武汉市第八医院肛肠医院肛肠外科,430010

出　　处：《中华胃肠外科杂志》2009年第5期474-476,共3页Chinese Journal of Gastrointestinal Surgery

基　　金：基金项目：武汉市创新体系与环境建设基金项目（2006003108-04）

摘　　要：目的 了解武汉地区结直肠癌的患病率，探索并分析开展城市居民恶性肿瘤二级预防的措施和序贯粪隐血筛检试验（SFOBT）方案的应用。方法采用整群分层随机抽样，选取19个筛查点的63961人作为目标人群，连续4年对筛查对象（40岁以上者）进行SFOBT，对阳性者行结肠镜精筛。结果目标人群中的筛查对象25837例（40．4％），接受SFOBT者7784例（30．1％），男女比例1．0：1．1．中位年龄56岁。SFOBT阳性者956例（12.3％），其中240例（25．1％）接受结肠镜检查，检出有病变者214例（89．2％），其中结直肠癌14例（6．5％），TNMⅠ、Ⅱ期11例，占检出结直肠癌的78．6％；结直肠腺瘤53例（24．8％）；直肠炎75例（35．0％）；溃疡性结肠炎5例（2.3％）；痔和肛门疾病65例（30．4％）；胃癌2例（0．8％）。结论武汉地区40岁以上人群结直肠癌的患病率为6．5％，SFOBT方案能比较有效地从目标人群中检出早期结直肠癌和癌前病变。Objective To evaluate the sequential fecal occult blood test （SFOBT） program for the screening of colorectal cancer and elucidate the prevalence of colorectal cancer in Wuhan area. Methods At 19 screening sites, 63 961 residents were recruited as target population according to random cluster and stratified sampling for four years （between 2005 and 2008）. Residents aged over 40 years old received SFOBT. Those with positive SFOBT underwent colonoscopy. Results The target population was 63 961. There were 25 837 people whose age was over 40. Finally,7784 participants received the SFOBT screening, with a medium age of 56 years old. The positive rate of SFOBT was 12.3% （956 persons）. Of the 956 persons, 240 participants underwent colonoscopy. Colorectal cancer was found in 14 cases（6.5%）, gastric cancer in 2 cases（0.9%）, colorectal adenoma in 53 cases （24.8%）, colorectal inflammation in 80 cases （37.3%） and hemorrhoids in 65 cases （30.4%）. Conclusions The prevalence of colorectal cancer is relatively high in Wuhan area. The SFOBT is available and feasible in screening early changes of colorectal cancer.

关 键 词：结直肠肿瘤 人群监测 结肠镜检查 序贯粪隐血筛查试验 

分 类 号：R735[医药卫生—肿瘤]