鸟苷蛋白在结直肠癌组织中的差异表达  

Differential expression of guanylin in colorectal cancer

作　　者：陈寅波[1] 朱玉萍[1] 冯海洋[1] 刘勇[1] 钱俊[1] 范永田[1] 李德川[1] 

机构地区：[1]浙江省肿瘤医院大肠外科,杭州310022

出　　处：《中华胃肠外科杂志》2009年第5期515-517,共3页Chinese Journal of Gastrointestinal Surgery

基　　金：基金项目：浙江省自然科学基金（Y2080634）

摘　　要：目的探讨鸟苷蛋白（guanylin）在人结直肠癌组织中的表达规律。方法应用RT—PCR和半定量分析方法对20例结直肠癌组织标本进行检测．并结合临床病理特点进行分析。结果guanylin基因在肿瘤组织和正常组织中的阳性表达率分别为35％（7／20）及80％（16／20），差异有统计学意义（P〈0．01）。其中14例具有差异表达的结直肠癌标本guanylin表达较正常肠黏膜明显降低．差异有统计学意义（P〈0．01）。guanylin的差异表达与结直肠患者的肿瘤TNM分期相关，而与患者性别、肿瘤大体类型和分化类型无关。结论guanylin在结直肠癌组织中呈低表达，其差异表达与肿瘤的TNM分期相关。Objective To investigate the expression of guanylin in colorectal cancer. Methods The expression of guanylin was examined by RT-PCR and semiquantitative analysis in 20 cases of colorectal cancer, and its relationship with clinical characteristics was analyzed. Results The positive expression of guanylin in normal tissue （80%,16/20） was significantly higher than that in tumor tissue （35% ,7/20）（P〈0.01 ）. The same result was found in the semiquantitative analysis of 14 cases with differential expression. Differential expression of guanylin in colorectal cancer was associate with TNM stage （P〈0.05）, not with sex, Borrmann type and degree of differentiation （all P〉0.05）. Conclusion There is differential expression of guanylin in colorectal cancer, and this kind of differential expression is associated with tumor TNM stage.

关 键 词：结直肠肿瘤 鸟苷蛋白 肿瘤分期 

分 类 号：R735[医药卫生—肿瘤]