口腔鳞癌中COX-2的表达与淋巴管生成的关系  

Relationship between the expression of Cyclooxygenase-2 and lymphangiogenesis in oral squamous cell carcinoma

作　　者：黄元清 宋宇峰[2] 张建国 唐中 

机构地区：[1]岳阳市第二医院口腔颌面外科,湖南岳阳414000 [2]贵阳医学院附属医院口腔颌面外科,贵州贵阳550004

出　　处：《临床口腔医学杂志》2009年第9期518-520,共3页Journal of Clinical Stomatology

基　　金：国家自然科学基金资助项目(30660200);贵州省优秀科技教育人才省长专项基金资助(2005-160)

摘　　要：目的:检测口腔鳞癌中环氧合酶-2(COX-2)和微淋巴管密度(MLVD)的表达,探讨COX-2与口腔鳞癌淋巴管生成的关系及临床意义。方法:应用免疫组织化学染色(S-P法)检测40例口腔鳞癌组织、14例正常口腔黏膜组织中COX-2的表达情况。应用免疫双重组织化学染色检测肿瘤中的MLVD。结果:COX-2在口腔鳞癌中的阳性表达率为70.0%,明显高于对照组(P<0.01)。COX-2的表达与口腔鳞癌颈淋巴结转移、TNM分期相关(P<0.05)。COX-2表达阳性组的MLVD值为23.3±1.9,显著高于阴性组的MLVD值16.9±2.2(t=9.295,P<0.01)。结论:COX-2在口腔鳞癌组织中表达明显上调,并与淋巴管生成、颈淋巴结转移及TNM分期等临床病理生物学行为有关,COX-2可能在口腔鳞癌的生长及转移中起重要作用。Objective：To detective the relationship between cyclooxygenase-2（COX-2） and lymphangiogenesis in oral squamous cell carcinoma（OSCC） and its clinical significance through observing the expression of COX-2 and determining microlymphatic vessel density（MLVD） in OSCC. Method：SP immunohistochemical technique was performed for detecting the expression of COX-2 in 40 OSCC tissues and 14 normal oral mucosa tissues. Immunohistochemical double staining technique was utilized to detect MLVD. Result：The positive rate of COX-2 protein in OSCC was 70.0%. The positive rate of COX-2 protein in normal control group was 14.3 %. There were significant differences between the two groups （P〈 0.01）. The high expression of COX-2 in OSCC was related to neck lymphnode metastasis and TNM stage （P 〈 0.05）. The MLVD value in COX-2-positive group was much higher than that in COX-2- negative group （t=9.295, P 〈 0.01）. Conclusion： Overexpression of COX-2 protein was involved in development of OSCC and correlated with clinicopathological features such as Lymphangiogenesis,neck lymph node metastasis and TNM stage.

关 键 词：口腔鳞癌 环氧合酶-2 微淋巴管密度 淋巴管生成 

分 类 号：R782[医药卫生—口腔医学] R739.8[医药卫生—临床医学]