大豆异黄酮及羧甲基纤维素钠对去卵巢大鼠体重、血脂的影响  

Effects of isoflavone and CMC-Na on body weight and blood lipids of ovariectomied rats

作　　者：张云波[1] 那晓琳[1] 赵新宇[1] 李丽娜[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院环境卫生学教研室,黑龙江哈尔滨150081

出　　处：《中国老年学杂志》2009年第17期2195-2197,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金(30671755);黑龙江省卫生厅项目(2006-300);哈尔滨医科大学研究生创新基金(HCXS2008006)

摘　　要：目的研究大豆异黄酮及羧甲基纤维素钠对去卵巢大鼠肥胖的预防作用以及对血脂的改善作用。方法清洁级7w龄SD雌性大鼠88只,随机分为两组,喂饲不同剂量的羧甲基纤维素钠。每组内部再根据体重随机分为6亚组,1亚组为单纯开腹术组,其他5组在无菌条件下切除双侧卵巢,喂饲不同剂量的大豆异黄酮。手术后给与高脂饲料诱导肥胖,实验组同时进行受试物灌胃。结果大豆异黄酮能显著降低去卵巢大鼠的体重、改善大鼠血脂水平,降低血清中总胆固醇(TC)、甘油三酯(TG)水平,升高高密度脂蛋白胆固醇(HDL-C)水平。羧甲基纤维素钠能显著降低大鼠体重,并与大豆异黄酮具有协同作用,但其对血脂的作用甚微。结论大豆异黄酮能够预防去卵巢大鼠的肥胖,并且改善血脂;羧甲基纤维素钠可显著减缓大鼠体重的增加,但对血脂水平影响甚微。Objective To investigate the beneficial effects of isoflavone and CMC-Na on obesity and blood lipids in ovariectomized rats. Methods Female 8-week-old SD rats were randomly divided into 2 groups and fed with different doses of CMC-Na. Each group was randomly divided into 6 groups according to body weight. There were sham control group （ SHAM）, ovariectomized control group （ OVX）, OVX with low-dose isoflavone （L-SI）, middle-dose isoflavone （M-SI） and high-dose isoflavone （H-SI）, and estrogen（EC） groups. All animals were allowed free access to high fat diet and water, and administrated with isoflavone, and then sacrificed 4 weeks later. Results Compared with OVX control group, rats＇ body weight were reduced in isoflavone groups. Serum TG, TC levels were reduced and HDL-C levels were increased in isoflavone groups. Body weight was reduced in high CMC-Na group. CMC-Na had a synergism effect with isoflavone. But there was no significant effect on blood lipids. Conclusions Isoflavone can reduce the body weight induced by OVX and improve blood lipids. CMC-Na can significantly reduce body weight, but there is little effect on blood lipids.

关 键 词：大豆异黄酮 羧甲基纤维素钠 肥胖 血脂 

分 类 号：R151.1[医药卫生—营养与食品卫生学] Q591[医药卫生—公共卫生与预防医学]