脑源性神经营养因子基因rs6265与抑郁障碍患者焦虑症状的关联分析  

Association analysis between BDNF gene polymorphism and the anxiety symptoms of depressive disorder in Chinese Han population

作　　者：刘莎[1] 任燕[1] 杨红[1] 赵新苗 刘伟 齐志宏 杨爱国 张克让[1] 

机构地区：[1]山西医科大学第一医院精神卫生科,太原030001 [2]忻州市荣军精神病医院 [3]临汾市荣军康复医院 [4]长治市精神卫生中心 [5]长治市郊区精神病院

出　　处：《中华行为医学与脑科学杂志》2009年第9期772-774,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：国家自然科学基金面上项目（30770770）;山西省科技攻关项目（2007031091.3）;国家人事部留学回国人员科研资助项目（2007-48）

摘　　要：目的探讨脑源性神经营养因子（BDNF）基因rs6265与抑郁障碍患者焦虑症状的关联性。方法采用聚合酶链反应技术（PCR）对458例抑郁障碍患者BDNF基因的多态性进行基因分型；运用汉密尔顿焦虑量表（HAMA）评估患者的焦虑症状及严重程度；采用数量性状分析比较不同等位基因及基因型间患者的焦虑症状是否有差异。结果①未发现抑郁障碍患者BDNF基因rs6265多态性与HAMA总分有关（等位基因：x2=1．947，P=0．163；基因型：x2=2．184，P=0．336）。②rs6265等位基因多态性与精神性焦虑因子及焦虑心境有关（x2=4．908，P=0．027；x2=4．312，P=0．038）。③未发现rs6265多态性与躯体性焦虑因子及其他条目有关（P〉0．05）。结论BDNF等位基因多态性可能与抑郁障碍的焦虑症状有关。Objective To explore the association of brain-derived neurotrophic factor （BDNF） gene poly- morphism and the anxiety symptoms of depressive disorder in Chinese Han population. Methods A total of 458 depressive patients diagnosed by DSM-IV were admitted in the study. The severity of depression and anxiety were respectively assessed with 17-item Hamilton Depression Rating Scale （17-HAMD） and Hamilton Anxiety Scale （ HAMA）. Polymerase chain reaction （PCR） and DNA direct sequencing technique were used to detect the genet- ic polymorphism of the BDNF gene. The analyses of the quantitative trait were performed by UNPHASED （ version 3.0）. Results There were no significant differences between HAMA score and polymorphism of the BDNF gene rs6265 （ alleles ： X2 = 1. 947, P = O. 163 ; genotypes ： X2 = 2. 184, P = 0. 336）. An association between the polymor- phism and the quantitative character of anxiety symptoms were observed in the allele （mental anxious factor：x2 = 4. 908 , P= 0.027 ; anxiousmood：x2 =4.312 ,P=O.038）,but not in thegenotype. Other item score of llAMA was showed no association with polymorphism of the BDNF gene rs6265 （P 〉 0.05）. Conclusion The polymor- phism in allele of BDNF gene may be associated with the anxiety symptoms of depressive patients. Polymorphism of the BDNF gene might constitute the appearance of the clinical manifestation-anxiety in depressive disorder. The re- sult also suggests that the analysis of symptom phenotype may be more suitable for genetic study of depressive dis- order.

关 键 词：抑郁障碍 焦虑 BDNF基因 多态性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]