慢性精神分裂症事件相关电位P300与认知功能成套测验的研究  

Study on Event-Related Potentials P300 and MCCB of Chronic Schizophrenia

作　　者：彭焱[1] 李建明[1] 王健[2] 邹义壮[2] 谭淑平[2] 张进国[2] 陈楠[2] 范宏振[2] 崔介峰[2] 

机构地区：[1]华北煤炭医学院心理系 [2]北京回龙观医院

出　　处：《中国健康心理学杂志》2009年第9期1025-1028,共4页China Journal of Health Psychology

摘　　要：目的探讨慢性精神分裂症P300的波幅、潜伏期的变化,及其与认知功能成套测验的关系。方法检测41例慢性精神分裂症患者(患者组)及40名正常人(对照组)Cz、Fz、Pz 3点的P300,并用认知功能成套测验(MCCB)评定其认知功能。结果与正常对照相比,在Cz、Fz、Pz 3点,患者组P300波幅降低,潜伏期延长;患者组女性波幅明显比男性高。P300与MCCB相关分析显示,Fz潜伏期与连线、符号编码及持续操作呈负相关;Cz潜伏期与连线、符号编码、言语记忆及迷宫呈负相关;Pz潜伏期与符号编码、迷宫及视觉记忆呈负相关;Pz波幅与符号编码、空间广度、迷宫及视觉记忆呈正相关。结论P300及MCCB可以反映出额叶、顶叶及枕叶的情况,将神经生理学与神经心理学结合起来,说明他们可以从两方面共同对大脑认知功能做出评定。Objective To explore the changes of the latency and amplitude of event-related potential （P300） in chronic schizophrenias, and the relation between event-related potential （P300） and MCCB. Methods The event-related potential （P300） at the Cz, Fz, Pz. of 41 chronic schizophrenia and 40 normal controls were measured. The cognition function were mea- sured with MATRICS Consensus Cognitive Battery （MCCB）. Results In comparison with normal controls, the patients had low- er amplitude and longer latency of P300 Cz, Fz, Pz. The female＇s amplitude were higher than the male＇s of the patients. The eor- relatign analysis of P300 and MCCB demonstrated that Fz latency and Trail Making A, symbol coding and Continuous Perfor- mance Test--Identical Pairs was a negative correlation; Cz latency and Trail Making A, symbol coding, Hopkins Verbal Learning Test--Revised and the Neuropsychological Assessment Battery--Mazes was a negative correlation; Pz latency and symbol coding, Neuropsychological Assessment Battery--Mazes and Brief Visuospatial Memory Test--Revised was a negatively correlation; Pz amplitude and symbol coding, Spacial Span, Neuropsychological Assessment Battery--Mazes and Brief Visuospatial Memory Test --Revised was a positively correlation. Conclusion P300 and MCCB can reflect the situation of frontal lobe, apical lobe and occip- ital lobe. Conjugation of neurophysiology and neuropsychology can evaluate the cognition function of cerebrum.

关 键 词：慢性精神分裂症 事件相关电位P300 潜伏期 波幅 精神分裂症认知功能成套测验 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R651.15[医药卫生—临床医学]