认知行为疗法对轻性抑郁障碍疗效及依从性对照研究  

Comparative Study on Efficacy of Cognitive-behavior Therapy and Pharmacotherapy and Compliance in Treatment of Minor Depression

作　　者：桑文华[1] 杜波[1] 张香云[1] 刘卉兰[1] 张彦恒[1] 魏昆岭[1] 齐国娥[1] 徐涛[1] 张旭静[1] 张平[1] 

机构地区：[1]中国.河北省精神卫生中心,保定市071000

出　　处：《中国健康心理学杂志》2009年第9期1046-1047,共2页China Journal of Health Psychology

摘　　要：目的比较单独认知行为疗法和帕罗西汀对轻性抑郁障碍患者的临床疗效及依从性差异。方法将64例轻性抑郁障碍患者分为认知行为治疗组和药物治疗组,治疗6周,利用汉密顿抑郁量表分别在治疗前、治疗后2、4、6周评定减分值及6周后疗效,并评定各期依从性。结果①治疗第6周末两组HAM D减分值差异有统计学意义(F=8.3,P=0);②帕罗汀治疗组和认知行为治疗组在第6周末疗效差异无统计学意义(u=316.5,P=0.06);③治疗初期2周时药物治疗组和认知行为治疗组在依从性上差异显著(u=385.5,P<0.05),4~6周治疗后,患者依从性没有显著差异(u=424.5和348.0,P>0.05)。结论单独认知行为治疗与药物治疗在一定程度上疗效相当,且患者依从性好。Objective To compare the clinical efficacy and compliance of cognitive--behavior therapy （CBT） and paroxetine in the treatment of minor depression. Methods Sixty--four patients with minor depression were divided into CBT and paroxetine groups with 32 patients respectively, and were treated for six weeks. The Hamilton Depression Scale （HAMD） was used to evalu- ate the clinical efficacy,compliance of the two groups were also recorded. Results （1）At the end of 6 weeks, significant difference was noted in the reduction of the HAMD score between the two groups（F= 8. 3 ,P= 0）. （2）No significant difference was found in the curative effects hetween the two groups （u= 316.5 ,P = 0. 06） at the end of 6 weeks. （3）At the original two weeks, there was significant difference in compliance between the two groups（u= 385.5,P,~0. 05）, While subsequent 4 to 6 weeks, there was no significant difference in compliance （u=424. 5 and 348. 0,P^0. 05）. Conclusion The clinical efficacy and compliance of cogni- tive-behavior therapy for minor depression seems to be similar to that of paroxetine.

关 键 词：认知行为疗法 抑郁障碍 帕罗西汀 病例对照研究 

分 类 号：R749.7[医药卫生—神经病学与精神病学] R563.8[医药卫生—临床医学]