Caveolin-1、Caveolae和动脉粥样硬化  

Caveolin-1,Caveolae and atherosclerosis

作　　者：刘定辉[1] 钱孝贤[1] 

机构地区：[1]中山大学附属第三医院心内科,广东广州510630

出　　处：《国际内科学杂志》2009年第9期509-511,531,共4页International Journal of Internal Medicine

基　　金：国家重点基础研究发展计划("973"计划;2005CB523305);广东省自然科学基金资助课题(8151008901000209);广东省科技计划项目资助课题(2007B060401024)

摘　　要：Caveolae是细胞表面直径为50～100nm的胞膜穴样内陷,主要由胆固醇、糖基鞘磷脂、鞘磷脂和一些结构蛋白如Caveolin组成。Caveolin-1是Caveolae的主要组成成分,它与细胞骨架蛋白间接偶联来维持Caveolae的内陷形态。Caveolae和Caveolin-1在参与动脉粥样硬化的各种细胞如内皮细胞、巨噬细胞、平滑肌细胞表面都有表达,它们通过对各种细胞功能和多个信号转导途径的调节参与对动脉粥样硬化的形成和发展。Caveolae are 50 -100 nm cell surface plasma membrane invaginations, which rich in cholesterol and sphingolipids. They are characterized by the presence of the protein marker caveolin-1, the structural protein responsible for maintaining the shape of Caveolae. Caveolae and caveolin-1 are present in almost every cell type that has been implicated in the development of antherosclerosis. They have an important functional role in the modulation of several signal transduction pathways and processes which may contribute to atheresclerosis.

关 键 词：动脉粥样硬化 CAVEOLAE CAVEOLIN-1 

分 类 号：R532.5[医药卫生—内科学]