基于瓦博格效应的肿瘤治疗新策略  

Novel Therapeutic Strategies for Cancer Chemotherapy Based on Warburg Effect

作　　者：邱嘉斌[1] 何玲[1] 

机构地区：[1]中国药科大学药理学教研室,江苏南京210009

出　　处：《药学进展》2009年第9期385-395,共11页Progress in Pharmaceutical Sciences

摘　　要：综述基于瓦博格效应(Warburg effect)的肿瘤治疗新策略,包括靶向低氧诱导因子(HIF-1α)信号通路以调控HIF-1α及其下游效应分子水平、靶向癌基因和抑癌基因以改变癌细胞代谢方式、直接干预有氧糖酵解以阻断肿瘤细胞能量供应和靶向酸性微环境以抑制肿瘤的侵袭和转移等。瓦博格效应所呈现的癌细胞能量代谢的生化特征改变涉及多基因、多分子和多水平的调控,为肿瘤的靶向治疗提供了契机,靶向有氧糖酵解过程而选择性杀灭肿瘤细胞的治疗策略具有广阔的临床开发和应用前景。The novel therapeutic strategies for cancer chemotherapy based on Warburg effect were reviewed, including targeting the HIF-1α pathway to regulate the levels of HIF-1α and its downstream effector molecules, targeting oncogenes and anti-oncogenes to switch cancer cell＇s metabolic mode, directly interfering with aerobic glycolysis to block the energy supply for cancer ceils and targeting the acidic extracellular environment to inhibit the tumor invasion and metastasis. The change in biochemical characterization in cancer cell energy metabolism, presented by Warburg effect, is modulated by a multi-gene or multi-protein system at different levels, which provides novel therapeutic strategies for targeted cancer therapies. Targeting glycolysis pathway to kill cancer cells is a promising therapeutic strategy in clinical development and application.

关 键 词：瓦博格效应 肿瘤 有氧糖酵解 能量代谢 低氧诱导因子 治疗策略 

分 类 号：R730.5[医药卫生—肿瘤]