罗伯逊易位分子机理初探  

The discussion on the Robertsonian translocation molecular mechanism

作　　者：胡方方[1] 韩从辉[1] 王一波[1] 梁志元 顾娟[1] 郝林[1] 惠红霞[3] 

机构地区：[1]江苏省徐州市中心医院生殖医学中心东南大学(徐州)生殖医学研究所,江苏徐州221009 [2]江苏省徐州市妇幼保健医院产科,江苏徐州221009 [3]江苏省徐州市中心医院检验科,江苏徐州221009

出　　处：《现代生物医学进展》2009年第15期2876-2878,共3页Progress in Modern Biomedicine

基　　金：徐州市科技计划社会发展资助项目(XM07C052)

摘　　要：目的:探讨复发性自然流产与染色体罗伯逊易位间的关系。方法:采用人外周血淋巴细胞培养,常规G显带技术行染色体核型检查,并结合临床资料对其进行分析。结果:57对复发性自然流产夫妇中,检出罗伯逊易位染色体核型4例,检出率3.51%。结论:罗伯逊易位是导致复发性流产的重要原因之一,对复发性自然流产患者进行常规的染色体检查及遗传咨询具有一定的临床意义。Objective： To analyze the relationship between Robertsonian translocation chromosomal karyotype and recurrent spontaneous abortions. Methods： Chromosomal karyotype studies were performed on routinely cultured lymphocytes. Slides were pro- cessed for G-banding with Tryp sin-Giemsa by standard techniques. Results： There were 4 Robertsonian translocation karyotypes in 57 couples with recurrent spontaneous abortions, the rate of abnormal karyotypes was 3.51%. Conclusions： The Robertsonian translocation was one of reasons of recurrent spontaneous abortions and the effect of chromosome heteromorphism was not beignored. It is necessary to analyse and genetic counselling in couples with recurrent spontaneous abortions.

关 键 词：罗伯逊易位 自然流产 分子机理 

分 类 号：R714.21[医药卫生—妇产科学] R714.21[医药卫生—临床医学]