p16、cyclin D1在消化道癌细胞周期调控中的关系探讨  

p16 and cyclin D1's effect in the cell cycle of digestive tract cancer cell

作　　者：任晓辉[1] 王珏[2] 姚智敏[2] 马学谦[2] 裴毅[1] 

机构地区：[1]山西省肿瘤医院,山西太原030013 [2]中国医科大学,辽宁沈阳110001

出　　处：《现代生物医学进展》2009年第15期2968-2970,共3页Progress in Modern Biomedicine

摘　　要：P16和cyclinD1是参与细胞周期调控及维持细胞正常增殖的关键蛋白,通过G1/S监测点即R点(restriction point)发挥调控作用。cyclinD1与CDK4/6(细胞周期依赖性激酶)结合形成cyclinD1/CDK4/6复合物,促使CDK4/6活化,细胞越过G1/S监测点进入细胞分裂周期。P16可重复地和特异性地与cyclinD1竞争调控CDK4/6,抑制两者的激酶活性,使细胞不能快速通过G1/S转换。由此可见,两者相辅相成、相互制约,其适时适度的表达是细胞周期得以正常运转的前提。近年来,大量的研究结果显示,P16基因的缺失及cyclinD1过度表达与恶性肿瘤发生、发展、及恶化关系密切。因此,对P16和cyclinD1的深入研究将有助于胃肠道肿瘤的分期、疗效判断、预后、转移、复发和治疗。P16 and cyclinD1 are involved in cell cycle regulation and maintenance of normal cell proliferation of the key protein. They play a regulatory role in the restriction point, cyclinD1 combined with CDK4 / 6 cyclinD1 / CDK4 / 6 complexes start the CDK4 / 6 and the cells to enter the cell division cycle. P16 can be repeated and specific competition with cyclinD1 control CDK4 / 6, inhibiting the kinase activity of both, so that cells can not be fast through the GI / S conversion. It can be seen that the two complement each other, mu- tual restraint, and its expression in a timely manner appropriate to the cell cycle is a prerequisite for normal operation. In recent years, a large number of studies have shown, P16 gene deletion and cyclinDl malignant over-expression and the occurrence and development of, and deterioration of close ties. Therefore, P16 and cyclinDl-depth study will contribute to the staging of gastrointestinal tumors, determine the efficacy, prognosis, metastasis and recurrence and treatment.

关 键 词：P16 CYCLIND1 细胞周期调控 胃肠道肿瘤 

分 类 号：R735[医药卫生—肿瘤]