川麦冬须根超细微粉的特征研究  

Characteristics of Ultra-fine Powder of Ophiopogon japonicus Fibrous Root

作　　者：张清东[1] 徐健蓉[1,2] 苟兴能[1] 舒晓燕[1] 王永生[2] 

机构地区：[1]西南科技大学,四川绵阳621010 [2]四川大学华西医院生物治疗国家重点实验室,四川成都610041

出　　处：《时珍国医国药》2009年第9期2134-2135,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金创新研究群体科学基金(No.30221001);西南科技大学人才引进基金(No.023110)

摘　　要：目的探索川麦冬须根普通粉和超细微粉间表面特性和溶出性的差异,以便更好地利用川麦冬须根资源。方法通过普通光学显微镜、电子显微镜对普通粉和超细微粉的形态学观察,通过对粒径、分布宽度、比表面积、松密度、压缩度及其浸出物测定等方法对其普通粉和超细微粉进行比较分析。结果与普通粉相比,超细微粉颗粒大小均匀,平均粒径D50为15.108μm,较普通粉降低5.8倍;松密度和压缩度下降;比表面积提高2.6倍;水、醇浸出物的干膏率分别增加45%和457%。结论川麦冬须根经超细粉碎后,颗粒大小分布均匀,均质度明显改善,比表面积及水、醇溶性物的溶出量显著增加,从而生物利用度提高。Objective To develop the fibrous root of Ophiopogonjaponicus （O. japonicus） by ultrafine powder （UFP） technology, and the powder characteristics, and the contents of water extract and ethanol extract were investigated between UFP and common powder （CP）. Methods The morphological characters of UFP and CP of the fibrous root of O. japonicus were observed with optional microscope, scanning electron microscope （ SEM）, respectively. Powder of the fibrous root of O. japonicus was characterized by laser diffraction analyzer and its compressibility and bulk density were measured. Furtherly, the water extract and ethanol extract were quantified by heated extraction. Results The differences of powder characteristics, surface morphology, the contents water extract and ethanol extract between CP and UFP were significant. The diameter of UFP was smaller （D50 = 15. 108μm） and a typical microscopic characters of the fibrous root of O. japonicus powder were not observed. The contents in water and enthanol extrat were increased by 45% and 457% respectively. Conclusion These data suggested that UFP might have a bright prospect in food or drug preparations with the fibrous root of O. japonicus.

关 键 词：超细微粉体 川麦冬 须根 溶出量 粉体学特征 

分 类 号：R282.6[医药卫生—中药学]