利拉萘酯的合成方法改进  

Optimization of synthesis technology for liranaftate

作　　者：金荣庆[1] 张海波[1] 孟霆[1] 陈言德[1] 

机构地区：[1]江苏(泰州)新药研究院扬子江药业集团有限公司,江苏泰州225321

出　　处：《中南药学》2009年第9期676-678,共3页Central South Pharmacy

摘　　要：目的对利拉萘酯的合成方法进行改进。方法以吡啶为原料,通过光氯气化、缩合、取代、对接等反应得到利拉萘酯。结果得到了目标化合物利拉萘酯,其熔点、红外光谱、NMR均与文献报道一致。结论此工艺稳定可行,原料易得、操作简单,适于利拉萘酯的开发与生产。Objective To improve the synthesis of liranaftate. Methods The target compound was synthesized from pyridine as a raw material via steps including light reaction of chlorine, condensation, substitution and condensation. Results The structure of the target compound was confirmed by melting point, IR analysis and NMR. Conclusion This cost-saving and simplified method can be used in industrial production.

关 键 词：利拉萘酯 抗真菌药 

分 类 号：R914.4[医药卫生—药物化学]